Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma

• Published in: BMC cancer Vol. 23; no. 1; pp. 241 - 14
• Main Authors: Huang, Junfeng, Hu, Bingqi, Yang, Ying, Liu, Huanhuan, Fan, Xingyu, Zhou, Jing, Chen, Liwen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.03.2023; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - genetics; Apoptosis; Biomarker; Cancer; CCT3; Cell cycle; Cell growth; Cell proliferation; Chaperonin Containing TCP-1 - genetics; Cytoskeleton; Dendritic cells; Development and progression; DNA methylation; DNA repair; Filaments; Flow cytometry; Gene expression; Genes; Genetic aspects; Genomes; Helper cells; Humans; Immune cell infiltration; Immunosuppression; Immunosuppressive Agents; Janus Kinases; Kinases; Lung adenocarcinoma; Lung cancer; Lung Neoplasms - genetics; Lymphocytes T; Mast cells; Medical prognosis; Molecular chaperones; Molecular modelling; mRNA; Nomograms; Oncology, Experimental; Prognosis; Proteasomes; Protein transport; Proteins; Regression analysis; Signal Transduction; siRNA; Software; STAT Transcription Factors; Survival analysis; T cell receptors; TCP1; Toll-like receptors; Tumor microenvironment; Tumor Microenvironment - genetics; Tumorigenesis; Tumors; China; CCT3; Immune cell infiltration; Biomarker; Lung adenocarcinoma; TCP1

Chaperonin-containing tailless complex polypeptide 1 (TCP1) subunit 3 (CCT3) has tumor-promoting effects in lung adenocarcinoma (LUAD). This study aims to investigate the molecular mechanisms of CCT3 in LUAD oncogenesis. The UALCAN databases, Human Protein Atlas (HPA) and The Cancer Genome Atlas (TC...