Genetic variegation of clonal architecture and propagating cells in leukaemia

• Published in: Nature (London) Vol. 469; no. 7330; pp. 356 - 361
• Main Authors: Anderson, Kristina, Lutz, Christoph, van Delft, Frederik W., Bateman, Caroline M., Guo, Yanping, Colman, Susan M., Kempski, Helena, Moorman, Anthony V., Titley, Ian, Swansbury, John, Kearney, Lyndal, Enver, Tariq, Greaves, Mel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.01.2011; Nature Publishing Group
• Subjects: 692/420/2489/144/68; 692/699/67/1990/283/2125; Animals; Artificial chromosomes; Biological and medical sciences; Cancer; Cell cycle; Clonal selection theory; Clone Cells - metabolism; Clone Cells - pathology; Core Binding Factor Alpha 2 Subunit; Disease Progression; DNA Copy Number Variations - genetics; DNA Mutational Analysis; Genetic abnormalities; Genetic aspects; Genetic Variation - genetics; Genetics; Genotype; Hematologic and hematopoietic diseases; Humanities and Social Sciences; Humans; Immunophenotyping; In Situ Hybridization, Fluorescence; Interleukin Receptor Common gamma Subunit - deficiency; Interleukin Receptor Common gamma Subunit - genetics; Leukemia; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mice; Mice, Inbred NOD; Mice, SCID; multidisciplinary; Mutation; Neoplasm Transplantation; Oncogene Proteins, Fusion - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Science; Science (multidisciplinary); United Kingdom; Human; Variegation; Propagation; Lymphoproliferative syndrome; Genetics; Malignant hemopathy; Genetic diversity; Acute lymphocytic leukemia; Cell; Child; Cancer; Clone

Little is known of the genetic architecture of cancer at the subclonal and single-cell level or in the cells responsible for cancer clone maintenance and propagation. Here we have examined this issue in childhood acute lymphoblastic leukaemia in which the ETV6–RUNX1 gene fusion is an early or initia...