Toxicity of nickel ions and comprehensive analysis of nickel ion-associated gene expression profiles in THP-1 cells

• Published in: Molecular medicine reports Vol. 12; no. 3; pp. 3273 - 3278
• Main Authors: ZHANG, YING, ZHANG, ZHI-WEI, XIE, YU-MEI, WANG, SHU-SHUI, QIU, QING-HUAN, ZHOU, YING-LING, ZENG, GUO-HONG
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.09.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Analysis; Apoptosis; Cardiovascular disease; Cell culture; Cell growth; Cell Line; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Congenital diseases; Coronary artery disease; CXCL16 protein; Cytokines; Cytotoxicity; Encyclopedias; Flow cytometry; Gene expression; Gene Expression Regulation - drug effects; Genomes; Genomics; Health aspects; Heart; Heart diseases; Humans; Illumina sequencing; Ions; Ions - toxicity; Leukemia; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Macrophages - pathology; Monocytes; Nickel; Nickel - toxicity; nickel ion; Polymerase chain reaction; RelB protein; Studies; THP-1 cell; Toxicity; Transcriptome - drug effects; Transforming growth factor-b1; China; United States > US

The aim of the present study was to explore the toxic effects and underlying mechanisms of nickel ions during therapeutic nickel-based alloy-treatment in congenital heart disease by investigating the metal-induced cytotoxicity to the human monocyte-derived macrophage cell line THP-1. THP-1 cells wer...