A family history study of intermittent explosive disorder
Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinica...
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| Published in | Journal of psychiatric research Vol. 44; no. 15; pp. 1101 - 1105 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
01.11.2010
Elsevier |
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| Online Access | Get full text |
| ISSN | 0022-3956 1879-1379 1879-1379 |
| DOI | 10.1016/j.jpsychires.2010.04.006 |
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| Abstract | Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.
Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.
Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.
IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. |
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| AbstractList | Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.BACKGROUNDIntermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.METHODSBlinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.RESULTSElevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.CONCLUSIONSIED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. Background Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. Methods Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. Results Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. Conclusions IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. [Copyright Elsevier Ltd.] Abstract Background Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. Methods Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. Results Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. Conclusions IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. Background: Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. Methods: Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. Results: Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. Conclusions: IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions. |
| Author | Coccaro, Emil F. |
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| Keywords | Intermittent Explosive Disorder Impulsivity Aggression Familial Studies Social environment Human Family story Impulse control disorder Family study Risk factor Mental health Intermittent explosive disorder Public health |
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| Snippet | Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under... Abstract Background Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and... Background: Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and... Background Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Aggression Aggression - psychology Biological and medical sciences Comorbidity Disruptive, Impulse Control, and Conduct Disorders - epidemiology Explosives Familial Studies Family Health Female Humans Impulsivity Indexing in process Intermittent Intermittent Explosive Disorder Male Medical sciences Middle Aged Miscellaneous Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Relatives Risk Factors Severity of Illness Index |
| Title | A family history study of intermittent explosive disorder |
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