Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities

• Published in: Journal of cerebral blood flow and metabolism Vol. 31; no. 10; pp. 1986 - 1998
• Main Authors: Zanotti-Fregonara, Paolo, Chen, Kewei, Liow, Jeih-San, Fujita, Masahiro, Innis, Robert B
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2011; Nature Publishing Group; Sage Publications Ltd
• Subjects: Biological and medical sciences; Brain - diagnostic imaging; Humans; Medical sciences; Neurology; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Positron-Emission Tomography - methods; Radiography; Review; Vascular diseases and vascular malformations of the nervous system; neuroreceptor tracers; image-derived input function; PET; kinetic modeling; Nervous system diseases; Modeling; Cerebral disorder; Encephalon; Central nervous system disease; Positron emission tomography; Cerebrovascular disease; Emission tomography; Tracers

Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging...