Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities

Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging...

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Published in	Journal of cerebral blood flow and metabolism Vol. 31; no. 10; pp. 1986 - 1998
Main Authors	Zanotti-Fregonara, Paolo, Chen, Kewei, Liow, Jeih-San, Fujita, Masahiro, Innis, Robert B
Format	Journal Article
Language	English
Published	London, England SAGE Publications 01.10.2011 Nature Publishing Group Sage Publications Ltd
Subjects	Biological and medical sciences Brain - diagnostic imaging Humans Medical sciences Neurology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Positron-Emission Tomography - methods Radiography Review Vascular diseases and vascular malformations of the nervous system neuroreceptor tracers image-derived input function PET kinetic modeling Nervous system diseases Modeling Cerebral disorder Encephalon Central nervous system disease Positron emission tomography Cerebrovascular disease Emission tomography Tracers
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Abstract	Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.
AbstractList	Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function. Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.
Author	Chen, Kewei Fujita, Masahiro Zanotti-Fregonara, Paolo Liow, Jeih-San Innis, Robert B
Author_xml	– sequence: 1 givenname: Paolo surname: Zanotti-Fregonara fullname: Zanotti-Fregonara, Paolo – sequence: 2 givenname: Kewei surname: Chen fullname: Chen, Kewei – sequence: 3 givenname: Jeih-San surname: Liow fullname: Liow, Jeih-San – sequence: 4 givenname: Masahiro surname: Fujita fullname: Fujita, Masahiro – sequence: 5 givenname: Robert B surname: Innis fullname: Innis, Robert B email: innisr@mail.nih.gov
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PublicationDate	2011-10-01
PublicationDateYYYYMMDD	2011-10-01
PublicationDate_xml	– month: 10 year: 2011 text: 2011-10-01 day: 01
PublicationDecade	2010
PublicationPlace	London, England
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PublicationTitle	Journal of cerebral blood flow and metabolism
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Publisher	SAGE Publications Nature Publishing Group Sage Publications Ltd
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Snippet	Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation....
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SubjectTerms	Biological and medical sciences Brain - diagnostic imaging Humans Medical sciences Neurology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Positron-Emission Tomography - methods Radiography Review Vascular diseases and vascular malformations of the nervous system
Title	Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities
URI	https://journals.sagepub.com/doi/full/10.1038/jcbfm.2011.107 https://www.ncbi.nlm.nih.gov/pubmed/21811289 https://www.proquest.com/docview/896284079 https://www.proquest.com/docview/896247652 https://www.proquest.com/docview/968173499 https://pubmed.ncbi.nlm.nih.gov/PMC3208145
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