Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene

• Published in: Oncogene Vol. 23; no. 44; pp. 7391 - 7398
• Main Authors: GIRAUD, Sandrine, HURLSTONE, Adam, AVRIL, Sylvie, COQUERET, Olivier
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 23.09.2004; Nature Publishing Group
• Subjects: Acetylation; Biological and medical sciences; BRG1 protein; Cell cycle; Cell Line, Tumor; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chromatin remodeling; Chromatin. Chromosome; Cyclin-dependent kinase 9; Cyclin-Dependent Kinase 9 - metabolism; Cyclin-Dependent Kinase Inhibitor p21; Cyclins - genetics; DNA Helicases; DNA-Binding Proteins - metabolism; DNA-directed RNA polymerase; Exons - genetics; Experiments; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genes; Histone H3; Histones; Humans; Immunoprecipitation; Interleukin-6 - pharmacology; Kinases; Molecular and cellular biology; Molecular genetics; Nuclear Proteins - metabolism; Phosphorylation; Promoter Regions, Genetic - genetics; Proteins; Recruitment; RNA polymerase; Stat3 protein; STAT3 Transcription Factor; Trans-Activators - metabolism; Transcription elongation; Transcription factors; Transcription Factors - metabolism; Transcription initiation; Transcription, Genetic - genetics; Transcriptional Activation; Tyrosine; Chromatin; p21waf1; CDKN1A Gene; STAT3; Chromosome; Activation; Acetylation; Carcinogenesis

STAT transcription factors (signal transducers and activators of transcription) are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT proteins translocate into the nucleus and activate specific target genes. We hav...