Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease

• Published in: Journal of neuropathology and experimental neurology Vol. 72; no. 2; pp. 130 - 136
• Main Authors: Beach, Thomas G., Adler, Charles H., Dugger, Brittany N., Serrano, Geidy, Hidalgo, Jose, Henry-Watson, Jonette, Shill, Holly A., Sue, Lucia I., Sabbagh, Marwan N., Akiyama, Haruhiko
• Format: Journal Article
• Language: English
• Published: England American Association of Neuropathologists, Inc 01.02.2013; Oxford University Press
• Subjects: Accuracy; Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Biomarkers; Biopsy; Brain - pathology; Brain research; Clinical trials; Colon; Dementia; Feasibility studies; Female; Humans; Lewy Body Disease - pathology; Life sciences; Male; Medical research; Medical treatment; Multiple System Atrophy - pathology; Muscle, Smooth - pathology; Nerve Fibers - pathology; Parkinson Disease - metabolism; Parkinson Disease - pathology; Submandibular Gland - metabolism; Submandibular Gland - pathology; Supranuclear Palsy, Progressive - pathology

ABSTRACTThe clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnos...