Macrophage polarization in the maculae of age-related macular degeneration: A pilot study

• Published in: Pathology international Vol. 61; no. 9; pp. 528 - 535
• Main Authors: Cao, Xiaoguang, Shen, Defen, Patel, Mrinali M., Tuo, Jingsheng, Johnson, T. Mark, Olsen, Timothy W., Chan, Chi-Chao
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.09.2011
• Subjects: age-related macular degeneration (AMD); Aged; Aged, 80 and over; Case-Control Studies; Cell Polarity; chemokine; Chemokine CCL22 - genetics; Chemokine CXCL11 - genetics; Choroid - pathology; Choroid - surgery; choroidal neovascularization; Choroidal Neovascularization - genetics; Choroidal Neovascularization - pathology; Choroidal Neovascularization - surgery; DNA, Complementary - genetics; Female; Humans; M1 macrophage; M2 macrophage; Macrophage Activation - immunology; Macrophages - cytology; Macrophages - immunology; Macula Lutea - pathology; Macular Degeneration - genetics; Macular Degeneration - pathology; Macular Degeneration - surgery; Male; Microdissection; Middle Aged; Phenotype; Pilot Projects; Retina - pathology; Retina - surgery; RNA, Messenger - genetics; Vascular Endothelial Growth Factors - genetics

Macrophages can be polarized to exhibit either pro‐inflammatory M1 or pro‐angiogenic M2 phenotypes, but have high phenotypic plasticity. This pilot study investigated macrophage polarization in the macular retina and choroid of age‐related macular degeneration (AMD) and non‐AMD subjects, as well as...