Spatiotemporal ablation of myelinating glia-specific neurofascin (NfascNF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains

• Published in: Journal of neuroscience research Vol. 87; no. 8; pp. 1773 - 1793
• Main Authors: Pillai, Anilkumar M., Thaxton, Courtney, Pribisko, Alaine L., Cheng, Jr-Gang, Dupree, Jeffrey L., Bhat, Manzoor A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2009
• Subjects: Animals; axoglial junctions; axonal domains; Axons - metabolism; Axons - pathology; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Demyelinating Diseases - genetics; Demyelinating Diseases - pathology; Demyelinating Diseases - physiopathology; Disease Models, Animal; Mice; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Movement Disorders - genetics; Movement Disorders - pathology; Movement Disorders - physiopathology; myelin; Myelin Proteolipid Protein - genetics; Myelin Proteolipid Protein - metabolism; Myelin Sheath - metabolism; Myelin Sheath - pathology; myelinated axons; Nerve Fibers, Myelinated - metabolism; Nerve Fibers, Myelinated - pathology; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; Neural Conduction - genetics; Neuroglia - metabolism; Neuroglia - pathology; paranodes; Peripheral Nerves - metabolism; Peripheral Nerves - pathology; Peripheral Nerves - physiopathology; Ranvier's Nodes - metabolism; Ranvier's Nodes - pathology; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Wallerian Degeneration - genetics; Wallerian Degeneration - pathology; Wallerian Degeneration - physiopathology

The evolutionary demand for rapid nerve impulse conduction led to the process of myelination‐dependent organization of axons into distinct molecular domains. These domains include the node of Ranvier flanked by highly specialized paranodal domains where myelin loops and axolemma orchestrate the axog...