A Protease Storm Cleaves a Cell-Cell Adhesion Molecule in Cancer: Multiple Proteases Converge to Regulate PTPmu in Glioma Cells

• Published in: Journal of cellular biochemistry Vol. 115; no. 9; pp. 1609 - 1623
• Main Authors: Phillips-Mason, Polly J., Craig, Sonya E.L., Brady-Kalnay, Susann M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2014; Wiley Subscription Services, Inc
• Subjects: ADAM; ADAM Proteins - metabolism; Adhesion; Brain Neoplasms - metabolism; Brain tumors; CALPAIN; Calpain - metabolism; Cell Adhesion Molecules - metabolism; Cell Line, Tumor; Cell Movement; FURIN; Furin - metabolism; Glioblastoma - metabolism; GLIOMA; Glycosylation; Humans; Membranes; Phosphorylation; PROTEIN TYROSINE PHOSPHATASE; PROTEOLYSIS; PROTEOLYSIS; SHEDDING; PTPmu; RECEPTOR PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; ADAM; CALPAIN; FURIN; SERINE PROTEASE; GLIOMA; PTPmu; RECEPTOR PROTEIN TYROSINE PHOSPHATASE; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - chemistry; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism; SERINE PROTEASE; SHEDDING; Storms; PROTEOLYSIS; SHEDDING; PTPmu; RECEPTOR PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; ADAM; CALPAIN; FURIN; SERINE PROTEASE; GLIOMA

Cleavage of the cell–cell adhesion molecule, PTPµ, occurs in human glioblastoma multiforme brain tumor tissue and glioma cell lines. PTPµ cleavage is linked to increased cell motility and growth factor independent survival of glioma cells in vitro. Previously, PTPµ was shown to be cleaved by furin i...