A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression

• Published in: Genesis (New York, N.Y. : 2000) Vol. 52; no. 7; pp. 702 - 712
• Main Authors: Dubail, Johanne, Aramaki-Hattori, Noriko, Bader, Hannah L., Nelson, Courtney M., Katebi, Negin, Matuska, Brittany, Olsen, Bjorn R., Apte, Suneel S.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2014; Wiley Subscription Services, Inc
• Subjects: A disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; ADAM Proteins - genetics; ADAMTS9 Protein; Alleles; Animals; apoptosis; cleft palate; Embryonic growth stage; Exons; Extremities - embryology; floxed; interdigital web; melanoblast; Mesoderm - metabolism; Mice; Mice, Inbred C57BL; Phenotype; Prx1-Cre; soft tissue syndactyly; Syndactyly - genetics; soft tissue syndactyly; melanoblast; Prx1-Cre; A disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; apoptosis; cleft palate; floxed; interdigital web

Summary ADAMTS9 is the most conserved member of a large family of secreted metalloproteases having diverse functions. Adamts9 null mice die before gastrulation, precluding investigations of its roles later in embryogenesis, in adult mice or disease models. We therefore generated a floxed Adamts9 all...