Long non-coding RNA regulation of reproduction and development

SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depe...

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Published in	Molecular reproduction and development Vol. 82; no. 12; pp. 932 - 956
Main Authors	Taylor, David H., Chu, Erin Tsi-Jia, Spektor, Roman, Soloway, Paul D.
Format	Journal Article
Language	English
Published	United States Blackwell Publishing Ltd 01.12.2015 Wiley Subscription Services, Inc
Subjects	Animals Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly - physiology Gene Expression Regulation, Developmental - physiology Genomic Imprinting - physiology Humans Reproduction - physiology RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism
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Abstract	SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small‐interfering RNAs and piwi‐interacting RNAs bound to Argonaute‐family proteins regulate post‐translational modifications on chromatin and local gene expression states. More recently, gene‐regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)—a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placentation, non‐genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionarily conserved processes lncRNAs are involved in. Mol. Reprod. Dev. 82: 932–956, 2015. © 2015 Wiley Periodicals, Inc.
AbstractList	Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small-interfering RNAs and piwi-interacting RNAs bound to Argonaute-family proteins regulate post-translational modifications on chromatin and local gene expression states. More recently, gene-regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)-a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placentation, non-genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionarily conserved processes lncRNAs are involved in. Mol. Reprod. Dev. 82: 932-956, 2015. copyright 2015 Wiley Periodicals, Inc. SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small‐interfering RNAs and piwi‐interacting RNAs bound to Argonaute‐family proteins regulate post‐translational modifications on chromatin and local gene expression states. More recently, gene‐regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)—a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placentation, non‐genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionarily conserved processes lncRNAs are involved in. Mol. Reprod. Dev. 82: 932–956, 2015. © 2015 Wiley Periodicals, Inc. Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small-interfering RNAs and piwi-interacting RNAs bound to Argonaute-family proteins regulate post-translational modifications on chromatin and local gene expression states. More recently, gene-regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)—a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placenta-tion, non-genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionary conserved processes lncRNAs are involved in. Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small-interfering RNAs and piwi-interacting RNAs bound to Argonaute-family proteins regulate post-translational modifications on chromatin and local gene expression states. More recently, gene-regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)--a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placentation, non-genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionarily conserved processes lncRNAs are involved in. SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs; transcriptional competence of sex chromosomes and some imprinted genes is regulated in cis by ncRNAs that vary by species; and both small-interfering RNAs and piwi-interacting RNAs bound to Argonaute-family proteins regulate post-translational modifications on chromatin and local gene expression states. More recently, gene-regulating noncoding RNAs have been identified, such as long intergenic and long noncoding RNAs (collectively referred to as lncRNAs)--a class totaling more than 100,000 transcripts in humans, which include some of the previously mentioned RNAs that regulate dosage compensation and imprinted gene expression. Here, we provide an overview of lncRNA activities, and then review the role of lncRNAs in processes vital to reproduction, such as germ cell specification, sex determination and gonadogenesis, sex hormone responses, meiosis, gametogenesis, placentation, non-genetic inheritance, and pathologies affecting reproductive tissues. Results from many species are presented to illustrate the evolutionarily conserved processes lncRNAs are involved in. Mol. Reprod. Dev. 82: 932-956, 2015. © 2015 Wiley Periodicals, Inc.
Author	Soloway, Paul D. Spektor, Roman Taylor, David H. Chu, Erin Tsi-Jia
AuthorAffiliation	1 Field of Genetics, Genomics and Development, Cornell University, Ithaca, New York 2 Field of Comparative Biomedical Sciences, Cornell University, Ithaca, New York 3 Division of Nutritional Sciences, Cornell University, Ithaca, New York
AuthorAffiliation_xml	– name: 1 Field of Genetics, Genomics and Development, Cornell University, Ithaca, New York – name: 3 Division of Nutritional Sciences, Cornell University, Ithaca, New York – name: 2 Field of Comparative Biomedical Sciences, Cornell University, Ithaca, New York
Author_xml	– sequence: 1 givenname: David H. surname: Taylor fullname: Taylor, David H. organization: Field of Genetics, Genomics and Development, Cornell University, New York, Ithaca – sequence: 2 givenname: Erin Tsi-Jia surname: Chu fullname: Chu, Erin Tsi-Jia organization: Field of Comparative Biomedical Sciences, Cornell University, New York, Ithaca – sequence: 3 givenname: Roman surname: Spektor fullname: Spektor, Roman organization: Field of Genetics, Genomics and Development, Cornell University, New York, Ithaca – sequence: 4 givenname: Paul D. surname: Soloway fullname: Soloway, Paul D. email: Correspondence author:Division of Nutritional SciencesCornell UniversityIthaca, NY 14853, soloway@cornell.edu organization: Field of Genetics, Genomics and Development, Cornell University, Ithaca, New York
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26517592$$D View this record in MEDLINE/PubMed
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60 e_1_2_7_153_1 e_1_2_7_176_1 e_1_2_7_199_1 e_1_2_7_213_1 e_1_2_7_236_1 e_1_2_7_259_1 e_1_2_7_138_1 e_1_2_7_251_1
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Snippet	SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that... Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of... SUMMARY Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that...
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SubjectTerms	Animals Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly - physiology Gene Expression Regulation, Developmental - physiology Genomic Imprinting - physiology Humans Reproduction - physiology RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism
Title	Long non-coding RNA regulation of reproduction and development
URI	https://api.istex.fr/ark:/67375/WNG-L4CPXRQ6-R/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmrd.22581 https://www.ncbi.nlm.nih.gov/pubmed/26517592 https://www.proquest.com/docview/1757581497 https://www.proquest.com/docview/1760897576 https://www.proquest.com/docview/1785233590 https://pubmed.ncbi.nlm.nih.gov/PMC4762656
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