PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas

• Published in: Molecular oncology Vol. 9; no. 2; pp. 450 - 462
• Main Authors: Bertonha, Fernanda Bernardi, Barros Filho, Mateus de Camargo, Kuasne, Hellen, dos Reis, Patricia Pintor, da Costa Prando, Erika, Muñoz, Juan José Augusto Moyano, Roffé, Martín, Hajj, Glaucia Noeli Maroso, Kowalski, Luiz Paulo, Rainho, Claudia Aparecida, Rogatto, Silvia Regina
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.02.2015; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; Amino acids; Blood cells; Breast carcinoma; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell adhesion & migration; Cell Line, Tumor; Chemotherapy; Chromatin; Chromosome 22; Chromosomes, Human, Pair 22 - genetics; Chromosomes, Human, Pair 22 - metabolism; Colon cancer; Copy number; Copy number alterations; CpG islands; DNA Methylation; DNA sequencing; DNA, Neoplasm - genetics; DNA, Neoplasm - metabolism; DNMT1 protein; Epigenesis, Genetic; Epigenetic changes; Family medical history; Female; Gene expression; Gene Expression Regulation; Gene Knockdown Techniques; Gene regulation; Head & neck cancer; Head and neck; Head and neck carcinoma; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; HNSCC; Human papillomavirus; Humans; Male; Medical records; Middle Aged; Mutation; Oral cancer; Peripheral blood; PHF21B; Proteins; Retrospective Studies; Squamous cell carcinoma; Studies; Tobacco; Transcription; Tumor cell lines; Tumor suppressor gene; Tumor suppressor genes; Tumor Suppressor Proteins - biosynthesis; Tumor Suppressor Proteins - genetics; Tumorigenesis; Tumors; MS-HRM; TSA; Epigenetic changes; HNSCC; 5-Aza-dC; qPCR; Copy number alterations; RT-qPCR; Tumor suppressor gene; PHF21B; ENCODE; HPV

A significant association between DNA losses on 22q13.31 and head and neck squamous cell carcinomas (HNSCC) was previously reported by our group. Our data indicated that PHF21B gene, mapped on 22q13.31 and encoding a protein with function of chromatin-mediated transcriptional regulation, might be a...