Esr1+ hypothalamic-habenula neurons shape aversive states

• Published in: Nature neuroscience Vol. 26; no. 7; pp. 1245 - 1255
• Main Authors: Calvigioni, Daniela, Fuzik, Janos, Le Merre, Pierre, Slashcheva, Marina, Jung, Felix, Ortiz, Cantin, Lentini, Antonio, Csillag, Veronika, Graziano, Marta, Nikolakopoulou, Ifigeneia, Weglage, Moritz, Lazaridis, Iakovos, Kim, Hoseok, Lenzi, Irene, Park, Hyunsoo, Reinius, Björn, Carlén, Marie, Meletis, Konstantinos
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2023; Nature Publishing Group
• Subjects: 13/51; 14/19; 38/91; 59; 631/378/1457/1601; 631/378/3920; 64/110; 64/60; 9/74; Affect; Animal Genetics and Genomics; Animals; Aversion; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Classification; Emotional behavior; Estrogen receptors; Estrogens; Female; Females; Glutamatergic transmission; Habenula; Habenula - physiology; Heterogeneity; Hypothalamic Area, Lateral; Hypothalamus; Hypothalamus (lateral); Hypothalamus - physiology; Luteinizing hormone; Mice; Neural coding; Neural Pathways - physiology; Neurobiology; Neurons; Neurons - physiology; Neuropeptide Y; Neurosciences; Prefrontal cortex; Receptors; Sensitivity; Sexual dimorphism; Structure-function relationships

Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal classification to define the structural and functional heterogeneity of the LHA–LHb pathway. Our classification identified si...