Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation - Norris, Paul C.; Skulas-Ray, Ann C.; Riley, Ian; Richter, Chesney K.; Kris-Etherton, Penny M.; Jensen, Gordon L.; Serhan, Charles N.; Maddipati, Krishna Rao (Scientific reports, 2018)
Keywords: 692/420/256/2516; 692/420/2780/262; Administration, Intravenous; Adult; Chromatography, Liquid; Dietary Supplements; Docosahexaenoic acid; Docosahexaenoic Acids - administration & dosage; Dose-Response Relationship, Drug; Eicosapentaenoic acid; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - analogs & derivatives; Endotoxins; Endotoxins - administration & dosage; Endotoxins - adverse effects; Esters; Fatty Acids, Omega-3 - administration & dosage; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Inflammation; Inflammation - chemically induced; Inflammation - diet therapy; Intravenous administration; Laboratories; Lipid Metabolism - drug effects; Lipopolysaccharides; Lipoxin A4; Male; Metabolome - drug effects; Metabolomics - methods; multidisciplinary; Plasma; Polyunsaturated fatty acids; Prostaglandins; Research Design - standards; Science; Science (multidisciplinary); Tandem Mass Spectrometry; Young Adult