Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 12; pp. 5534 - 5539
• Main Authors: Theodossis, Alex, Guillonneau, Carole, Welland, Andrew, Ely, Lauren K, Clements, Craig S, Williamson, Nicholas A, Webb, Andrew I, Wilce, Jacqueline A, Mulder, Roger J, Dunstone, Michelle A, Doherty, Peter C, McCluskey, James, Purcell, Anthony W, Turner, Stephen J, Rossjohn, Jamie
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.03.2010; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; ARGININE; Atomic interactions; Atoms; BASIC BIOLOGICAL SCIENCES; Biological Sciences; cytotoxicity; Epitopes; Epitopes - chemistry; Epitopes - genetics; Epitopes - metabolism; Female; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; Genetic mutation; GENETICS; GLYCOPROTEINS; H-2 Antigens - chemistry; H-2 Antigens - genetics; H-2 Antigens - metabolism; Histocompatibility Antigen H-2D; Histocompatibility Antigens Class I - chemistry; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - metabolism; HISTOCOMPATIBILITY COMPLEX; HLA-B Antigens - chemistry; HLA-B Antigens - genetics; HLA-B Antigens - metabolism; HLA-B44 Antigen; Humans; Immunity; INFLUENZA; Ligands; LYMPHOCYTES; major histocompatibility complex; Major histocompatibility complex genes; Mice; Mice, Inbred C57BL; MINING; Models, Molecular; Mutagenesis, Site-Directed; Mutation; MUTATIONS; Peptide Fragments - chemistry; Peptide Fragments - genetics; Peptide Fragments - immunology; PEPTIDES; Protein Conformation; PROTEINS; receptors; RESIDUES; T cell antigen receptors; T cell receptors; T lymphocytes; T-Lymphocytes - immunology; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - immunology; Viruses

Residues within processed protein fragments bound to major histocompatibility complex class I (MHC-I) glycoproteins have been considered to function as a series of "independent pegs" that either anchor the peptide (p) to the MHC-I and/or interact with the spectrum of αβ-T-cell receptors (T...