A Simple and Powerful Analysis of Lateral Subdiffusion Using Single Particle Tracking

• Published in: Biophysical journal Vol. 113; no. 11; pp. 2452 - 2463
• Main Authors: Renner, Marianne, Wang, Lili, Levi, Sabine, Hennekinne, Laetitia, Triller, Antoine
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.12.2017; Biophysical Society; The Biophysical Society
• Subjects: Animals; Biochemistry, Molecular Biology; Biological membranes; Biophysics; Cell Biophysics; Cell Membrane - metabolism; Cytoskeleton; Diffusion; Diffusion effects; Lateral diffusion; Life Sciences; Lipid composition; Lipids; Mathematical analysis; Membranes; Molecular interactions; Molecules; Neurons - cytology; Particle tracking; Random walk; Rats; Receptors; Scaffolding; Single Molecule Imaging; Synapses

In biological membranes, many factors such as cytoskeleton, lipid composition, crowding, and molecular interactions deviate lateral diffusion from the expected random walks. These factors have different effects on diffusion but act simultaneously, so the observed diffusion is a complex mixture of di...