Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and drug-gene Interaction Network

• Published in: Frontiers in pharmacology Vol. 12; p. 764279
• Main Authors: Umetsu, Ryogo, Tanaka, Mizuki, Nakayama, Yoko, Kato, Yamato, Ueda, Natsumi, Nishibata, Yuri, Hasegawa, Shiori, Matsumoto, Kiyoka, Takeyama, Noriaki, Iguchi, Kazuhiro, Tanaka, Hiroyuki, Hinoi, Eiichi, Inagaki, Naoki, Inden, Masatoshi, Muto, Yoshinori, Nakamura, Mitsuhiro
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.12.2021
• Subjects: drug-gene intraction; enrichment analysis; food and drug administration adverse event reporting system; montelukast; neuropsychiatric adverse events; Pharmacology; protein-protein interaction; food and drug administration adverse event reporting system; drug-gene intraction; protein-protein interaction; neuropsychiatric adverse events; montelukast; enrichment analysis

Montelukast is a selective leukotriene receptor antagonist that is widely used to treat bronchial asthma and nasal allergy. To clarify the association between montelukast and neuropsychiatric adverse events (AEs), we evaluated case reports recorded between January 2004 and December 2018 in the Food...