Suppression of the pathogenicity of Candida albicans by the quorum-sensing molecules farnesol and tryptophol

• Published in: Journal of general and applied microbiology Vol. 65; no. 6; pp. 277 - 283
• Main Authors: Pumeesat, Potjaman, Muangkaew, Watcharamat, Wongsuk, Thanwa, Suwanmanee, San, Singkum, Pantira, Luplertlop, Natthanej
• Format: Journal Article
• Language: English
• Published: Japan Applied Microbiology, Molecular and Cellular Biosciences Research Foundation 01.01.2019; Japan Science and Technology Agency
• Subjects: Apoptosis; Candida albicans; Cell death; Farnesol; Fungi; Fungicides; Galleria mellonella; Gene expression; Genes; germ tube; In vivo methods and tests; Larvae; Mushrooms; Pathogenicity; Pathogens; Pretreatment; quorum-sensing molecules; tryptophol; Virulence; Candida albicans; Galleria mellonella; germ tube; quorum-sensing molecules; tryptophol

This study examines the ability of the quorum-sensing molecules (QSMs) farnesol and tryptophol to induce programmed cell death of the pathogenic fungus Candida albicans, to alter the expression of apoptosis-related genes, and to reduce the pathogenicity and virulence of C. albicans in Galleria mello...