Suppression of the pathogenicity of Candida albicans by the quorum-sensing molecules farnesol and tryptophol

This study examines the ability of the quorum-sensing molecules (QSMs) farnesol and tryptophol to induce programmed cell death of the pathogenic fungus Candida albicans, to alter the expression of apoptosis-related genes, and to reduce the pathogenicity and virulence of C. albicans in Galleria mello...

Full description

Saved in:
Bibliographic Details
Published inJournal of general and applied microbiology Vol. 65; no. 6; pp. 277 - 283
Main Authors Pumeesat, Potjaman, Muangkaew, Watcharamat, Wongsuk, Thanwa, Suwanmanee, San, Singkum, Pantira, Luplertlop, Natthanej
Format Journal Article
LanguageEnglish
Published Japan Applied Microbiology, Molecular and Cellular Biosciences Research Foundation 01.01.2019
Japan Science and Technology Agency
Subjects
Apoptosis
Candida albicans
Cell death
Farnesol
Fungi
Fungicides
Galleria mellonella
Gene expression
Genes
germ tube
In vivo methods and tests
Larvae
Mushrooms
Pathogenicity
Pathogens
Pretreatment
quorum-sensing molecules
tryptophol
Virulence
Candida albicans
Galleria mellonella
germ tube
quorum-sensing molecules
tryptophol
Online AccessGet full text

Cover

More Information
Summary:This study examines the ability of the quorum-sensing molecules (QSMs) farnesol and tryptophol to induce programmed cell death of the pathogenic fungus Candida albicans, to alter the expression of apoptosis-related genes, and to reduce the pathogenicity and virulence of C. albicans in Galleria mellonella. Our results showed that both farnesol and tryptophol inhibited C. albicans germ tube formation. In the QSM-treated group, the expression levels of the apoptosis genes increased, whereas the expression level of the anti-apoptosis gene decreased. Further, pretreatment of C. albicans with tryptophol or farnesol prior to G. mellonella larval infection significantly enhanced host survival compared with larvae infected with untreated C. albicans. Thus, farnesol and tryptophol may trigger apoptosis of C. albicans in vitro and reduce the virulence of C. albicans in vivo. Although further study is needed to identify the precise mechanisms underlying the antifungal properties of farnesol and tryptophol, these results suggest that QSMs may be effective agents for controlling fungal infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0022-1260
1349-8037
DOI:10.2323/jgam.2018.12.002