Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer

• Published in: International journal of oncology Vol. 50; no. 4; pp. 1087 - 1096
• Main Authors: Li, Jie, Li, Qiang, Huang, He, Li, Yinguang, Li, Li, Hou, Wenhui, You, Zeshan
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.04.2017; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Apoptosis; Binding sites; Biomarkers; Care and treatment; Cell cycle; Cell growth; Development and progression; Gene expression; Genetic aspects; Health aspects; Kinases; Lymphoma; Medical prognosis; Medical research; Metastasis; MicroRNA; Mortality; Ovarian cancer; Patients; Penicillin; Plasmids; Roles; Studies

MicroRNAs are a class of small non-coding, endogenous RNAs involved in cancer development and progression. MicroRNA-221 (mir-221) has been reported to have both an oncogenic and tumor-suppressive role in human tumors, but the role of miR-221 in ovarian cancer is poorly understood. In the present stu...