Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats

• Published in: Ecotoxicology and environmental safety Vol. 74; no. 4; pp. 607 - 614
• Main Authors: Jain, Anshu, Yadav, Abhishek, Bozhkov, A.I., Padalko, V.I., Flora, S.J.S.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.05.2011; Elsevier
• Subjects: Animal, plant and microbial ecology; Animals; antioxidant activity; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Applied ecology; Arsenic; Arsenic - metabolism; Arsenic Poisoning - drug therapy; Arsenic Poisoning - metabolism; Arsenic toxicity; Arsenites - toxicity; Biological and medical sciences; blood; Catalase; Catalase - metabolism; Chelating Agents - therapeutic use; Chelation; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; chronic exposure; cytotoxicity; Damage; Ecotoxicology, biological effects of pollution; Environmental Pollutants - metabolism; Flavanones - pharmacology; Flavanones - therapeutic use; Flavonoids; Fundamental and applied biological sciences. Psychology; General aspects; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Male; Naringenin; oral administration; Oxidative stress; Oxidative Stress - drug effects; protective effect; Rat; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; Recovery; Silymarin; Silymarin - pharmacology; Silymarin - therapeutic use; Sod; sodium arsenite; Sodium Compounds - toxicity; superoxide dismutase; Superoxide Dismutase - metabolism; Thiobarbituric Acid Reactive Substances - metabolism; thiobarbituric acid-reactive substances; Tissue arsenic concentration; Antioxidants; Oxidative stress; Arsenic toxicity; Flavonoids; Naringenin; Silymarin; Rat; Tissue arsenic concentration; Chelation; Arsenic; Ecotoxicology; Toxicity; Rodentia; Antioxidant; Flavonoid; Heavy metal; Concentration measurement; Pollutant; Vertebrata; Mammalia; Silibinin; Environment; Damage

We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were chronically exposed to sodium arsenite for eight months followed by oral treatment with silymarin and naringenin (50 mg/kg each) for 15 consecutive d...