Baculovirus as a Tool for Gene Delivery and Gene Therapy

• Published in: Viruses Vol. 10; no. 9; p. 510
• Main Authors: Ono, Chikako, Okamoto, Toru, Abe, Takayuki, Matsuura, Yoshiharu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.09.2018; MDPI
• Subjects: Apoptosis; baculovirus expression vectors; Cell culture; CpG islands; Deoxyribonucleic acid; DNA; Epitopes; Gene expression; Gene therapy; Gene transfer; Genomes; Hepatitis C; HIV; Human immunodeficiency virus; Immune response; Infections; Inflammation; Innate immunity; Insect cells; Interferon; Mammalian cells; Propagation; Proteins; Review; Signal transduction; Toll-like receptors; Vectors; Virology; Viruses; gene therapy; mammalian cells; baculovirus expression vectors; insect cells

Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalia...