Baculovirus as a Tool for Gene Delivery and Gene Therapy
Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalia...
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| Published in | Viruses Vol. 10; no. 9; p. 510 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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19.09.2018
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| Abstract | Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral replication. However, several CpG motifs are present throughout baculoviral DNA and induce an antiviral response in mammalian cells, resulting in the production of pro-inflammatory cytokines and type I interferon through a Toll-like receptor (TLR)-dependent or -independent signaling pathway, and ultimately limiting the efficiency of transgene expression. On the other hand, by taking advantage of this strong adjuvant activity, recombinant baculoviruses encoding neutralization epitopes can elicit protective immunity in mice. Moreover, immunodeficient cells, such as hepatitis C virus (HCV)- or human immunodeficiency virus (HIV)-infected cells, are more susceptible to baculovirus infection than normal cells and are selectively eliminated by the apoptosis-inducible recombinant baculovirus. Here, we summarize the application of baculovirus as a gene expression vector and the mechanism of the host innate immune response induced by baculovirus in mammalian cells. We also discuss the future prospects of baculovirus vectors. |
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| AbstractList | Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral replication. However, several CpG motifs are present throughout baculoviral DNA and induce an antiviral response in mammalian cells, resulting in the production of pro-inflammatory cytokines and type I interferon through a Toll-like receptor (TLR)-dependent or -independent signaling pathway, and ultimately limiting the efficiency of transgene expression. On the other hand, by taking advantage of this strong adjuvant activity, recombinant baculoviruses encoding neutralization epitopes can elicit protective immunity in mice. Moreover, immunodeficient cells, such as hepatitis C virus (HCV)- or human immunodeficiency virus (HIV)-infected cells, are more susceptible to baculovirus infection than normal cells and are selectively eliminated by the apoptosis-inducible recombinant baculovirus. Here, we summarize the application of baculovirus as a gene expression vector and the mechanism of the host innate immune response induced by baculovirus in mammalian cells. We also discuss the future prospects of baculovirus vectors. Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral replication. However, several CpG motifs are present throughout baculoviral DNA and induce an antiviral response in mammalian cells, resulting in the production of pro-inflammatory cytokines and type I interferon through a Toll-like receptor (TLR)-dependent or -independent signaling pathway, and ultimately limiting the efficiency of transgene expression. On the other hand, by taking advantage of this strong adjuvant activity, recombinant baculoviruses encoding neutralization epitopes can elicit protective immunity in mice. Moreover, immunodeficient cells, such as hepatitis C virus (HCV)- or human immunodeficiency virus (HIV)-infected cells, are more susceptible to baculovirus infection than normal cells and are selectively eliminated by the apoptosis-inducible recombinant baculovirus. Here, we summarize the application of baculovirus as a gene expression vector and the mechanism of the host innate immune response induced by baculovirus in mammalian cells. We also discuss the future prospects of baculovirus vectors.Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral replication. However, several CpG motifs are present throughout baculoviral DNA and induce an antiviral response in mammalian cells, resulting in the production of pro-inflammatory cytokines and type I interferon through a Toll-like receptor (TLR)-dependent or -independent signaling pathway, and ultimately limiting the efficiency of transgene expression. On the other hand, by taking advantage of this strong adjuvant activity, recombinant baculoviruses encoding neutralization epitopes can elicit protective immunity in mice. Moreover, immunodeficient cells, such as hepatitis C virus (HCV)- or human immunodeficiency virus (HIV)-infected cells, are more susceptible to baculovirus infection than normal cells and are selectively eliminated by the apoptosis-inducible recombinant baculovirus. Here, we summarize the application of baculovirus as a gene expression vector and the mechanism of the host innate immune response induced by baculovirus in mammalian cells. We also discuss the future prospects of baculovirus vectors. |
| Author | Ono, Chikako Okamoto, Toru Matsuura, Yoshiharu Abe, Takayuki |
| AuthorAffiliation | 2 Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan; atakayu@med.kobe-u.ac.jp 1 Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; chikaono@biken.osaka-u.ac.jp (C.O.); toru@biken.osaka-u.ac.jp (T.O.) |
| AuthorAffiliation_xml | – name: 1 Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; chikaono@biken.osaka-u.ac.jp (C.O.); toru@biken.osaka-u.ac.jp (T.O.) – name: 2 Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan; atakayu@med.kobe-u.ac.jp |
| Author_xml | – sequence: 1 givenname: Chikako surname: Ono fullname: Ono, Chikako – sequence: 2 givenname: Toru surname: Okamoto fullname: Okamoto, Toru – sequence: 3 givenname: Takayuki surname: Abe fullname: Abe, Takayuki – sequence: 4 givenname: Yoshiharu surname: Matsuura fullname: Matsuura, Yoshiharu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30235841$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/ni1303 10.1128/JVI.75.2.961-970.2001 10.1128/JVI.02007-07 10.1016/0042-6822(86)90031-0 10.1128/JVI.01778-08 10.1073/pnas.93.6.2348 10.1128/JVI.78.16.8663-8672.2004 10.1007/s10565-009-9133-y 10.1128/JVI.79.24.15452-15459.2005 10.1073/pnas.92.22.10099 10.1038/nature12862 10.1128/JVI.73.12.9944-9951.1999 10.1186/1471-2199-10-87 10.1099/vir.0.82664-0 10.1371/journal.pone.0148578 10.1016/S0002-9440(10)64557-9 10.1099/vir.0.010397-0 10.1371/journal.pone.0005093 10.1016/0042-6822(86)90019-X 10.1128/JVI.01919-13 10.1016/j.celrep.2017.08.085 10.1126/science.1244040 10.1128/JVI.06357-11 10.1158/0008-5472.CAN-05-4514 10.1016/j.virol.2017.08.023 10.1016/0042-6822(89)90445-5 10.1128/JVI.02165-10 10.1007/s00705-009-0423-8 10.1128/JVI.06704-11 10.3748/wjg.14.5810 10.1016/S0065-3527(06)68003-2 10.1128/JVI.03055-13 10.1073/pnas.0508531102 10.1128/jvi.67.8.4566-4579.1993 10.1128/jvi.60.1.224-229.1986 10.1038/sj.gt.3301246 10.1128/JVI.80.8.4135-4146.2006 10.1128/JVI.73.4.3404-3409.1999 10.4049/jimmunol.171.3.1133 10.1128/JVI.79.6.3639-3652.2005 10.4161/bioe.22966 10.1126/science.1232458 10.1038/sj.gt.3302657 10.1016/j.jbiotec.2007.01.037 10.1128/JVI.77.18.9799-9808.2003 10.1016/0042-6822(89)90276-6 10.1016/j.bbrc.2005.12.133 10.1016/j.virusres.2012.02.016 10.1128/jvi.56.1.153-160.1985 10.1016/j.bbrc.2011.01.032 10.1016/j.vaccine.2009.11.044 10.1038/gt.2017.78 10.1128/jvi.67.4.2149-2158.1993 10.1186/1472-6750-10-80 10.1128/JVI.79.5.2847-2858.2005 10.1128/JVI.00880-06 10.1016/S0168-1656(02)00023-8 10.1016/j.jbiotec.2004.05.014 10.1126/science.1229963 10.1099/0022-1317-78-10-2657 10.1038/mt.2009.22 10.1128/jvi.67.5.2664-2671.1993 10.1002/(SICI)1521-2254(199903/04)1:2<93::AID-JGM19>3.0.CO;2-1 10.1099/vir.0.012138-0 10.1016/j.bbrc.2006.08.184 10.1128/JVI.00679-09 10.1038/315592a0 10.1006/viro.2000.0699 10.1099/vir.0.19270-0 10.1038/90609 10.1128/CVI.00285-07 10.1099/0022-1317-68-5-1233 |
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| References | Wang (ref_66) 2006; 66 Friesen (ref_16) 1986; 131 Beck (ref_57) 2000; 7 Li (ref_63) 2013; 341 ref_13 Kitajima (ref_12) 2008; 15 Long (ref_38) 2006; 80 Makkonen (ref_36) 2013; 87 Carbonell (ref_1) 1985; 56 Gronowski (ref_11) 1999; 73 Akira (ref_58) 2001; 2 Wang (ref_29) 2009; 90 Sun (ref_61) 2013; 339 Blissard (ref_23) 1989; 170 Vijayachandran (ref_26) 2013; 4 Sinn (ref_45) 2017; 24 Luckow (ref_7) 1993; 67 Ono (ref_27) 2012; 165 Duisit (ref_34) 1999; 1 Li (ref_69) 2005; 102 Blissard (ref_22) 1989; 168 Huang (ref_68) 2008; 14 Matilainen (ref_39) 2005; 79 Guarino (ref_20) 1986; 60 Zhou (ref_56) 2008; 82 Hodgson (ref_28) 2011; 85 Wu (ref_62) 2013; 339 Kenoutis (ref_72) 2006; 80 Lu (ref_55) 2006; 340 Heinimaki (ref_71) 2017; 511 Chapple (ref_41) 2002; 95 Takahama (ref_65) 2017; 20 Abe (ref_8) 2003; 171 Makela (ref_42) 2006; 68 Passarelli (ref_21) 1993; 67 Liu (ref_73) 2007; 88 Fortunati (ref_33) 2001; 75 Martyn (ref_50) 2009; 154 Yang (ref_19) 1999; 73 Balani (ref_67) 2009; 17 ref_31 Taka (ref_32) 2013; 82 ref_74 Abe (ref_9) 2005; 79 Kitagawa (ref_54) 2005; 79 Kaikkonen (ref_52) 2006; 13 Lee (ref_48) 2010; 28 Leisy (ref_18) 1986; 153 Wu (ref_35) 2012; 86 Boyce (ref_3) 1996; 93 Tani (ref_6) 2001; 279 Borg (ref_43) 2004; 114 Facciabene (ref_51) 2004; 78 Nobiron (ref_25) 2003; 84 Hitchman (ref_30) 2010; 26 Kaneko (ref_53) 2006; 349 Cullen (ref_70) 2000; 157 Schoggins (ref_64) 2014; 505 Leisy (ref_17) 1986; 153 Ge (ref_47) 2007; 129 Maeda (ref_15) 1985; 315 ref_40 Matsuura (ref_14) 1987; 68 Ono (ref_60) 2014; 88 Hofmann (ref_2) 1995; 92 Chen (ref_46) 2011; 405 ref_49 Tani (ref_5) 2003; 77 Abe (ref_10) 2009; 83 Shoji (ref_4) 1997; 78 Kataoka (ref_37) 2012; 86 Chaabihi (ref_24) 1993; 67 Liu (ref_75) 2009; 83 Kawai (ref_59) 2006; 7 Yu (ref_44) 2009; 90 16424890 - Nat Immunol. 2006 Feb;7(2):131-7 23258413 - Science. 2013 Feb 15;339(6121):786-91 8474166 - J Virol. 1993 May;67(5):2664-71 19240692 - Mol Ther. 2009 Jun;17(6):1003-11 28930687 - Cell Rep. 2017 Sep 19;20(12):2944-2954 9349488 - J Gen Virol. 1997 Oct;78 ( Pt 10):2657-64 2989694 - Nature. 1985 Jun 13-19;315(6020):592-4 21289117 - J Virol. 2011 Apr;85(8):3918-29 12874198 - J Immunol. 2003 Aug 1;171(3):1133-9 10074194 - J Virol. 1999 Apr;73(4):3404-9 16571829 - J Virol. 2006 Apr;80(8):4135-46 8392598 - J Virol. 1993 Aug;67(8):4566-79 12941888 - J Virol. 2003 Sep;77(18):9799-808 3526710 - Virology. 1986 Sep;153(2):280-8 19474102 - J Virol. 2009 Aug;83(15):7629-40 2993646 - J Virol. 1985 Oct;56(1):153-60 28880020 - Gene Ther. 2017 Oct;24(10):674-679 7479733 - Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10099-103 23926339 - J Virol. 2013 Oct;87(20):11148-59 11477402 - Nat Immunol. 2001 Aug;2(8):675-80 16405916 - Biochem Biophys Res Commun. 2006 Feb 24;340(4):1178-83 15709004 - J Virol. 2005 Mar;79(5):2847-58 19725957 - BMC Mol Biol. 2009 Sep 02;10:87 3553425 - J Gen Virol. 1987 May;68 ( Pt 5):1233-50 15731258 - J Virol. 2005 Mar;79(6):3639-52 19193807 - J Virol. 2009 Apr;83(8):3604-16 19961961 - Vaccine. 2010 Feb 10;28(6):1613-9 14573808 - J Gen Virol. 2003 Nov;84(Pt 11):3029-39 23989956 - Science. 2013 Sep 20;341(6152):1390-4 17622620 - J Gen Virol. 2007 Aug;88(Pt 8):2176-84 19474242 - J Gen Virol. 2009 Sep;90(Pt 9):2282-7 17374412 - J Biotechnol. 2007 May 1;129(3):367-72 22072779 - J Virol. 2012 Jan;86(1):484-91 22190715 - J Virol. 2012 Mar;86(5):2610-20 2644736 - Virology. 1989 Feb;168(2):354-62 2658304 - Virology. 1989 Jun;170(2):537-55 15280475 - J Virol. 2004 Aug;78(16):8663-72 19264658 - J Gen Virol. 2009 Jul;90(Pt 7):1641-8 10559307 - J Virol. 1999 Dec;73(12):9944-51 16789259 - J Virol. 1986 Oct;60(1):224-9 16997010 - Adv Virus Res. 2006;68:91-112 16912330 - J Virol. 2006 Sep;80(17):8830-3 15464595 - J Biotechnol. 2004 Oct 19;114(1-2):21-30 16979590 - Biochem Biophys Res Commun. 2006 Nov 3;349(4):1220-7 8637876 - Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2348-52 19655260 - Cell Biol Toxicol. 2010 Feb;26(1):57-68 3526709 - Virology. 1986 Sep;153(2):157-67 16267571 - Gene Ther. 2006 Feb;13(4):304-12 16740719 - Cancer Res. 2006 Jun 1;66(11):5798-806 23328086 - Bioengineered. 2013 Sep-Oct;4(5):279-87 10934149 - Am J Pathol. 2000 Aug;157(2):449-61 18057182 - Clin Vaccine Immunol. 2008 Feb;15(2):376-8 19352496 - PLoS One. 2009;4(4):e5093 22421381 - Virus Res. 2012 May;165(2):197-206 16306616 - J Virol. 2005 Dec;79(24):15452-9 11145915 - Virology. 2001 Jan 5;279(1):343-53 21092083 - BMC Biotechnol. 2010 Nov 19;10:80 8445724 - J Virol. 1993 Apr;67(4):2149-58 21219863 - Biochem Biophys Res Commun. 2011 Feb 11;405(2):297-302 11134309 - J Virol. 2001 Jan;75(2):961-70 24335288 - J Virol. 2014 Feb;88(4):2157-67 24284630 - Nature. 2014 Jan 30;505(7485):691-5 16301520 - Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17717-22 26863132 - PLoS One. 2016 Feb 10;11(2):e0148578 23258412 - Science. 2013 Feb 15;339(6121):826-30 28843813 - Virology. 2017 Nov;511:114-122 10738573 - J Gene Med. 1999 Mar-Apr;1(2):93-102 18855978 - World J Gastroenterol. 2008 Oct 14;14(38):5810-5 17989172 - J Virol. 2008 Feb;82(3):1368-77 3816299 - Curr Top Microbiol Immunol. 1986;131:31-49 10918498 - Gene Ther. 2000 Aug;7(15):1274-83 19557497 - Arch Virol. 2009;154(7):1129-38 12007867 - J Biotechnol. 2002 May 23;95(3):269-75 |
| References_xml | – volume: 7 start-page: 131 year: 2006 ident: ref_59 article-title: Innate immune recognition of viral infection publication-title: Nat. Immunol. doi: 10.1038/ni1303 – volume: 75 start-page: 961 year: 2001 ident: ref_33 article-title: Baculovirus infection of nondividing mammalian cells: Mechanisms of entry and nuclear transport of capsids publication-title: J. Virol. doi: 10.1128/JVI.75.2.961-970.2001 – volume: 82 start-page: 1368 year: 2008 ident: ref_56 article-title: Display of heterologous proteins on gp64null baculovirus virions and enhanced budding mediated by a vesicular stomatitis virus G-stem construct publication-title: J. Virol. doi: 10.1128/JVI.02007-07 – volume: 153 start-page: 280 year: 1986 ident: ref_17 article-title: The nucleotide sequence of the polyhedrin gene region from the multicapsid baculovirus of Orgyia pseudotsugata publication-title: Virology doi: 10.1016/0042-6822(86)90031-0 – volume: 83 start-page: 3604 year: 2009 ident: ref_75 article-title: RING and coiled-coil domains of baculovirus IE2 are critical in strong activation of the cytomegalovirus major immediate-early promoter in mammalian cells publication-title: J. Virol. doi: 10.1128/JVI.01778-08 – volume: 93 start-page: 2348 year: 1996 ident: ref_3 article-title: Baculovirus-mediated gene transfer into mammalian cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.93.6.2348 – volume: 78 start-page: 8663 year: 2004 ident: ref_51 article-title: Baculovirus vectors elicit antigen-specific immune responses in mice publication-title: J. Virol. doi: 10.1128/JVI.78.16.8663-8672.2004 – volume: 26 start-page: 57 year: 2010 ident: ref_30 article-title: Genetic modification of a baculovirus vector for increased expression in insect cells publication-title: Cell Biol. Toxicol. doi: 10.1007/s10565-009-9133-y – volume: 79 start-page: 15452 year: 2005 ident: ref_39 article-title: Baculovirus entry into human hepatoma cells publication-title: J. Virol. doi: 10.1128/JVI.79.24.15452-15459.2005 – volume: 92 start-page: 10099 year: 1995 ident: ref_2 article-title: Efficient gene transfer into human hepatocytes by baculovirus vectors publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.22.10099 – volume: 505 start-page: 691 year: 2014 ident: ref_64 article-title: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity publication-title: Nature doi: 10.1038/nature12862 – volume: 131 start-page: 31 year: 1986 ident: ref_16 article-title: The regulation of baculovirus gene expression publication-title: Curr. Top. Microbiol. Immunol. – volume: 73 start-page: 9944 year: 1999 ident: ref_11 article-title: Baculovirus stimulates antiviral effects in mammalian cells publication-title: J. Virol. doi: 10.1128/JVI.73.12.9944-9951.1999 – ident: ref_31 doi: 10.1186/1471-2199-10-87 – volume: 88 start-page: 2176 year: 2007 ident: ref_73 article-title: Stimulation of baculovirus transcriptome expression in mammalian cells by baculoviral transcriptional activators publication-title: J. Gen. Virol. doi: 10.1099/vir.0.82664-0 – ident: ref_74 doi: 10.1371/journal.pone.0148578 – volume: 157 start-page: 449 year: 2000 ident: ref_70 article-title: The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)64557-9 – volume: 90 start-page: 1641 year: 2009 ident: ref_29 article-title: Characterization of a virion occlusion-defective Autographa californica multiple nucleopolyhedrovirus mutant lacking the p26, p10 and p74 genes publication-title: J. Gen. Virol. doi: 10.1099/vir.0.010397-0 – ident: ref_40 doi: 10.1371/journal.pone.0005093 – volume: 153 start-page: 157 year: 1986 ident: ref_18 article-title: Nucleotide sequencing and transcriptional mapping of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus p10 gene publication-title: Virology doi: 10.1016/0042-6822(86)90019-X – volume: 87 start-page: 11148 year: 2013 ident: ref_36 article-title: 6-o- and N-sulfated syndecan-1 promotes baculovirus binding and entry into mammalian cells publication-title: J. Virol. doi: 10.1128/JVI.01919-13 – volume: 20 start-page: 2944 year: 2017 ident: ref_65 article-title: The RAB2b-GARIL5 complex promotes cytosolic DNA-induced innate immune responses publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.08.085 – volume: 341 start-page: 1390 year: 2013 ident: ref_63 article-title: Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects publication-title: Science doi: 10.1126/science.1244040 – volume: 86 start-page: 484 year: 2012 ident: ref_35 article-title: A pH-sensitive heparin-binding sequence from Baculovirus gp64 protein is important for binding to mammalian cells but not to Sf9 insect cells publication-title: J. Virol. doi: 10.1128/JVI.06357-11 – volume: 66 start-page: 5798 year: 2006 ident: ref_66 article-title: Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-4514 – volume: 511 start-page: 114 year: 2017 ident: ref_71 article-title: Live baculovirus acts as a strong B and T cell adjuvant for monomeric and oligomeric protein antigens publication-title: Virology doi: 10.1016/j.virol.2017.08.023 – volume: 170 start-page: 537 year: 1989 ident: ref_23 article-title: Location, sequence, transcriptional mapping, and temporal expression of the gp64 envelope glycoprotein gene of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus publication-title: Virology doi: 10.1016/0042-6822(89)90445-5 – volume: 85 start-page: 3918 year: 2011 ident: ref_28 article-title: Interaction of Autographa californica multiple nucleopolyhedrovirus cathepsin protease progenitor (proV-CATH) with insect baculovirus chitinase as a mechanism for proV-CATH cellular retention publication-title: J. Virol. doi: 10.1128/JVI.02165-10 – volume: 154 start-page: 1129 year: 2009 ident: ref_50 article-title: Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors publication-title: Arch Virol. doi: 10.1007/s00705-009-0423-8 – volume: 86 start-page: 2610 year: 2012 ident: ref_37 article-title: Baculovirus GP64-mediated entry into mammalian cells publication-title: J. Virol. doi: 10.1128/JVI.06704-11 – ident: ref_13 – volume: 14 start-page: 5810 year: 2008 ident: ref_68 article-title: Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.5810 – volume: 68 start-page: 91 year: 2006 ident: ref_42 article-title: Baculovirus display: A multifunctional technology for gene delivery and eukaryotic library development publication-title: Adv. Virus Res. doi: 10.1016/S0065-3527(06)68003-2 – volume: 88 start-page: 2157 year: 2014 ident: ref_60 article-title: Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells publication-title: J.Virol. doi: 10.1128/JVI.03055-13 – volume: 102 start-page: 17717 year: 2005 ident: ref_69 article-title: Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0508531102 – volume: 67 start-page: 4566 year: 1993 ident: ref_7 article-title: Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli publication-title: J. Virol. doi: 10.1128/jvi.67.8.4566-4579.1993 – volume: 60 start-page: 224 year: 1986 ident: ref_20 article-title: Complete sequence and enhancer function of the homologous DNA regions of Autographa californica nuclear polyhedrosis virus publication-title: J. Virol. doi: 10.1128/jvi.60.1.224-229.1986 – volume: 7 start-page: 1274 year: 2000 ident: ref_57 article-title: Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes publication-title: Gene Ther. doi: 10.1038/sj.gt.3301246 – volume: 80 start-page: 4135 year: 2006 ident: ref_72 article-title: Baculovirus-mediated gene delivery into mammalian cells does not alter their transcriptional and differentiating potential but is accompanied by early viral gene expression publication-title: J. Virol. doi: 10.1128/JVI.80.8.4135-4146.2006 – volume: 73 start-page: 3404 year: 1999 ident: ref_19 article-title: Activation of baculovirus very late promoters by interaction with very late factor 1 publication-title: J. Virol. doi: 10.1128/JVI.73.4.3404-3409.1999 – volume: 171 start-page: 1133 year: 2003 ident: ref_8 article-title: Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice publication-title: J. Immunol. doi: 10.4049/jimmunol.171.3.1133 – volume: 79 start-page: 3639 year: 2005 ident: ref_54 article-title: Ligand-directed gene targeting to mammalian cells by pseudotype baculoviruses publication-title: J. Virol. doi: 10.1128/JVI.79.6.3639-3652.2005 – volume: 4 start-page: 279 year: 2013 ident: ref_26 article-title: Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering publication-title: Bioengineered doi: 10.4161/bioe.22966 – volume: 339 start-page: 786 year: 2013 ident: ref_61 article-title: Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway publication-title: Science doi: 10.1126/science.1232458 – volume: 13 start-page: 304 year: 2006 ident: ref_52 article-title: Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo publication-title: Gene Ther. doi: 10.1038/sj.gt.3302657 – volume: 129 start-page: 367 year: 2007 ident: ref_47 article-title: A surface-modified baculovirus vector with improved gene delivery to B-lymphocytic cells publication-title: J. Biotechnol. doi: 10.1016/j.jbiotec.2007.01.037 – volume: 77 start-page: 9799 year: 2003 ident: ref_5 article-title: In vitro and in vivo gene delivery by recombinant baculoviruses publication-title: J. Virol. doi: 10.1128/JVI.77.18.9799-9808.2003 – volume: 168 start-page: 354 year: 1989 ident: ref_22 article-title: Nucleotide sequence, transcriptional mapping, and temporal expression of the gene encoding p39, a major structural protein of the multicapsid nuclear polyhedrosis virus of Orgyia pseudotsugata publication-title: Virology doi: 10.1016/0042-6822(89)90276-6 – volume: 340 start-page: 1178 year: 2006 ident: ref_55 article-title: Suppression of porcine arterivirus replication by baculovirus-delivered shRNA targeting nucleoprotein publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.12.133 – volume: 165 start-page: 197 year: 2012 ident: ref_27 article-title: Phenotypic grouping of 141 BmNPVs lacking viral gene sequences publication-title: Virus Res. doi: 10.1016/j.virusres.2012.02.016 – volume: 56 start-page: 153 year: 1985 ident: ref_1 article-title: Baculovirus-mediated expression of bacterial genes in dipteran and mammalian cells publication-title: J. Virol. doi: 10.1128/jvi.56.1.153-160.1985 – volume: 405 start-page: 297 year: 2011 ident: ref_46 article-title: Membrane penetrating peptides greatly enhance baculovirus transduction efficiency into mammalian cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.01.032 – volume: 28 start-page: 1613 year: 2010 ident: ref_48 article-title: Development of a novel viral DNA vaccine against human papillomavirus: AcHERV-HP16L1 publication-title: Vaccine doi: 10.1016/j.vaccine.2009.11.044 – volume: 24 start-page: 674 year: 2017 ident: ref_45 article-title: Novel GP64 envelope variants for improved delivery to human airway epithelial cells publication-title: Gene Ther. doi: 10.1038/gt.2017.78 – volume: 67 start-page: 2149 year: 1993 ident: ref_21 article-title: Three baculovirus genes involved in late and very late gene expression: Ie-1, ie-n, and lef-2 publication-title: J. Virol. doi: 10.1128/jvi.67.4.2149-2158.1993 – ident: ref_49 doi: 10.1186/1472-6750-10-80 – volume: 79 start-page: 2847 year: 2005 ident: ref_9 article-title: Involvement of the toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus publication-title: J. Virol. doi: 10.1128/JVI.79.5.2847-2858.2005 – volume: 80 start-page: 8830 year: 2006 ident: ref_38 article-title: Functional entry of baculovirus into insect and mammalian cells is dependent on clathrin-mediated endocytosis publication-title: J. Virol. doi: 10.1128/JVI.00880-06 – volume: 95 start-page: 269 year: 2002 ident: ref_41 article-title: Non-polar distribution of green fluorescent protein on the surface of Autographa californica nucleopolyhedrovirus using a heterologous membrane anchor publication-title: J. Biotechnol. doi: 10.1016/S0168-1656(02)00023-8 – volume: 82 start-page: 25 year: 2013 ident: ref_32 article-title: Complex genetic interactions among non-essential genes of BmNPV revealed by multiple gene knockout analysis publication-title: J. Insect Biotechnol. Sericol. – volume: 114 start-page: 21 year: 2004 ident: ref_43 article-title: Amino-terminal anchored surface display in insect cells and budded baculovirus using the amino-terminal end of neuraminidase publication-title: J. Biotechnol. doi: 10.1016/j.jbiotec.2004.05.014 – volume: 339 start-page: 826 year: 2013 ident: ref_62 article-title: Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA publication-title: Science doi: 10.1126/science.1229963 – volume: 78 start-page: 2657 year: 1997 ident: ref_4 article-title: Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-78-10-2657 – volume: 17 start-page: 1003 year: 2009 ident: ref_67 article-title: High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment publication-title: Mol. Ther. doi: 10.1038/mt.2009.22 – volume: 67 start-page: 2664 year: 1993 ident: ref_24 article-title: Competition between baculovirus polyhedrin and p10 gene expression during infection of insect cells publication-title: J. Virol. doi: 10.1128/jvi.67.5.2664-2671.1993 – volume: 1 start-page: 93 year: 1999 ident: ref_34 article-title: Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells publication-title: J. Gene Med. doi: 10.1002/(SICI)1521-2254(199903/04)1:2<93::AID-JGM19>3.0.CO;2-1 – volume: 90 start-page: 2282 year: 2009 ident: ref_44 article-title: Transduction of vertebrate cells with Spodoptera exigua multiple nucleopolyhedrovirus F protein-pseudotyped gp64-null Autographa californica multiple nucleopolyhedrovirus publication-title: J. Gen. Virol. doi: 10.1099/vir.0.012138-0 – volume: 349 start-page: 1220 year: 2006 ident: ref_53 article-title: Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2006.08.184 – volume: 83 start-page: 7629 year: 2009 ident: ref_10 article-title: Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner publication-title: J. Virol. doi: 10.1128/JVI.00679-09 – volume: 315 start-page: 592 year: 1985 ident: ref_15 article-title: Production of human alpha-interferon in silkworm using a baculovirus vector publication-title: Nature doi: 10.1038/315592a0 – volume: 279 start-page: 343 year: 2001 ident: ref_6 article-title: Characterization of cell-surface determinants important for baculovirus infection publication-title: Virology doi: 10.1006/viro.2000.0699 – volume: 84 start-page: 3029 year: 2003 ident: ref_25 article-title: Autographa californica nucleopolyhedrovirus infection of spodoptera frugiperda cells: A global analysis of host gene regulation during infection, using a differential display approach publication-title: J. Gen. Virol. doi: 10.1099/vir.0.19270-0 – volume: 2 start-page: 675 year: 2001 ident: ref_58 article-title: Toll-like receptors: Critical proteins linking innate and acquired immunity publication-title: Nat. Immunol. doi: 10.1038/90609 – volume: 15 start-page: 376 year: 2008 ident: ref_12 article-title: Induction of antitumor acquired immunity by baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mice publication-title: Clin. Vaccine Immunol. doi: 10.1128/CVI.00285-07 – volume: 68 start-page: 1233 year: 1987 ident: ref_14 article-title: Baculovirus expression vectors: The requirements for high level expression of proteins, including glycoproteins publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-68-5-1233 – reference: 19655260 - Cell Biol Toxicol. 2010 Feb;26(1):57-68 – reference: 2658304 - Virology. 1989 Jun;170(2):537-55 – reference: 21289117 - J Virol. 2011 Apr;85(8):3918-29 – reference: 19961961 - Vaccine. 2010 Feb 10;28(6):1613-9 – reference: 16301520 - Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17717-22 – reference: 8392598 - J Virol. 1993 Aug;67(8):4566-79 – reference: 2989694 - Nature. 1985 Jun 13-19;315(6020):592-4 – reference: 19240692 - Mol Ther. 2009 Jun;17(6):1003-11 – reference: 16267571 - Gene Ther. 2006 Feb;13(4):304-12 – reference: 19474102 - J Virol. 2009 Aug;83(15):7629-40 – reference: 17374412 - J Biotechnol. 2007 May 1;129(3):367-72 – reference: 22072779 - J Virol. 2012 Jan;86(1):484-91 – reference: 11477402 - Nat Immunol. 2001 Aug;2(8):675-80 – reference: 19474242 - J Gen Virol. 2009 Sep;90(Pt 9):2282-7 – reference: 22190715 - J Virol. 2012 Mar;86(5):2610-20 – reference: 15280475 - J Virol. 2004 Aug;78(16):8663-72 – reference: 9349488 - J Gen Virol. 1997 Oct;78 ( Pt 10):2657-64 – reference: 16912330 - J Virol. 2006 Sep;80(17):8830-3 – reference: 8445724 - J Virol. 1993 Apr;67(4):2149-58 – reference: 23989956 - Science. 2013 Sep 20;341(6152):1390-4 – reference: 10559307 - J Virol. 1999 Dec;73(12):9944-51 – reference: 11145915 - Virology. 2001 Jan 5;279(1):343-53 – reference: 14573808 - J Gen Virol. 2003 Nov;84(Pt 11):3029-39 – reference: 23926339 - J Virol. 2013 Oct;87(20):11148-59 – reference: 28880020 - Gene Ther. 2017 Oct;24(10):674-679 – reference: 3816299 - Curr Top Microbiol Immunol. 1986;131:31-49 – reference: 3526709 - Virology. 1986 Sep;153(2):157-67 – reference: 16306616 - J Virol. 2005 Dec;79(24):15452-9 – reference: 12941888 - J Virol. 2003 Sep;77(18):9799-808 – reference: 22421381 - Virus Res. 2012 May;165(2):197-206 – reference: 23258412 - Science. 2013 Feb 15;339(6121):826-30 – reference: 8637876 - Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2348-52 – reference: 15464595 - J Biotechnol. 2004 Oct 19;114(1-2):21-30 – reference: 23328086 - Bioengineered. 2013 Sep-Oct;4(5):279-87 – reference: 19352496 - PLoS One. 2009;4(4):e5093 – reference: 3526710 - Virology. 1986 Sep;153(2):280-8 – reference: 16997010 - Adv Virus Res. 2006;68:91-112 – reference: 11134309 - J Virol. 2001 Jan;75(2):961-70 – reference: 10738573 - J Gene Med. 1999 Mar-Apr;1(2):93-102 – reference: 21219863 - Biochem Biophys Res Commun. 2011 Feb 11;405(2):297-302 – reference: 15731258 - J Virol. 2005 Mar;79(6):3639-52 – reference: 2644736 - Virology. 1989 Feb;168(2):354-62 – reference: 12007867 - J Biotechnol. 2002 May 23;95(3):269-75 – reference: 16740719 - Cancer Res. 2006 Jun 1;66(11):5798-806 – reference: 8474166 - J Virol. 1993 May;67(5):2664-71 – reference: 18855978 - World J Gastroenterol. 2008 Oct 14;14(38):5810-5 – reference: 26863132 - PLoS One. 2016 Feb 10;11(2):e0148578 – reference: 10918498 - Gene Ther. 2000 Aug;7(15):1274-83 – reference: 21092083 - BMC Biotechnol. 2010 Nov 19;10:80 – reference: 28930687 - Cell Rep. 2017 Sep 19;20(12):2944-2954 – reference: 16424890 - Nat Immunol. 2006 Feb;7(2):131-7 – reference: 19725957 - BMC Mol Biol. 2009 Sep 02;10:87 – reference: 3553425 - J Gen Virol. 1987 May;68 ( Pt 5):1233-50 – reference: 17622620 - J Gen Virol. 2007 Aug;88(Pt 8):2176-84 – reference: 23258413 - Science. 2013 Feb 15;339(6121):786-91 – reference: 24335288 - J Virol. 2014 Feb;88(4):2157-67 – reference: 19264658 - J Gen Virol. 2009 Jul;90(Pt 7):1641-8 – reference: 15709004 - J Virol. 2005 Mar;79(5):2847-58 – reference: 18057182 - Clin Vaccine Immunol. 2008 Feb;15(2):376-8 – reference: 19557497 - Arch Virol. 2009;154(7):1129-38 – reference: 10074194 - J Virol. 1999 Apr;73(4):3404-9 – reference: 28843813 - Virology. 2017 Nov;511:114-122 – reference: 24284630 - Nature. 2014 Jan 30;505(7485):691-5 – reference: 16405916 - Biochem Biophys Res Commun. 2006 Feb 24;340(4):1178-83 – reference: 16789259 - J Virol. 1986 Oct;60(1):224-9 – reference: 7479733 - Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10099-103 – reference: 12874198 - J Immunol. 2003 Aug 1;171(3):1133-9 – reference: 19193807 - J Virol. 2009 Apr;83(8):3604-16 – reference: 17989172 - J Virol. 2008 Feb;82(3):1368-77 – reference: 16571829 - J Virol. 2006 Apr;80(8):4135-46 – reference: 16979590 - Biochem Biophys Res Commun. 2006 Nov 3;349(4):1220-7 – reference: 10934149 - Am J Pathol. 2000 Aug;157(2):449-61 – reference: 2993646 - J Virol. 1985 Oct;56(1):153-60 |
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| SubjectTerms | Apoptosis baculovirus expression vectors Cell culture CpG islands Deoxyribonucleic acid DNA Epitopes Gene expression Gene therapy Gene transfer Genomes Hepatitis C HIV Human immunodeficiency virus Immune response Infections Inflammation Innate immunity Insect cells Interferon Mammalian cells Propagation Proteins Review Signal transduction Toll-like receptors Vectors Virology Viruses |
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| Title | Baculovirus as a Tool for Gene Delivery and Gene Therapy |
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