Ex vivo oocyte retrieval for fertility preservation in an adolescent patient with recurrent ovarian dysgerminoma: a case report and review of the literature
To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique. Case report and literature review. A 17-year-old female with a medical history of righ...
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| Published in | F&S Reports (Online) Vol. 6; no. 2; pp. 208 - 215 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.06.2025
Elsevier |
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| ISSN | 2666-3341 2666-3341 |
| DOI | 10.1016/j.xfre.2025.01.017 |
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| Abstract | To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique.
Case report and literature review.
A 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy.
The patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a “mobile IVF” setup.
Number of meiosis II oocytes cryopreserved.
A total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy.
The combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy. |
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| AbstractList | Objective: To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique. Design: Case report and literature review. Subjects: A 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy. Exposure: The patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a “mobile IVF” setup. Main Outcome Measure(s): Number of meiosis II oocytes cryopreserved. Results: A total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy. Conclusion: The combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy. To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique. Case report and literature review. A 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy. The patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a “mobile IVF” setup. Number of meiosis II oocytes cryopreserved. A total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy. The combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy. To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique.ObjectiveTo describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique.Case report and literature review.DesignCase report and literature review.A 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy.SubjectsA 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy.The patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a "mobile IVF" setup.ExposureThe patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a "mobile IVF" setup.Number of meiosis II oocytes cryopreserved.Main Outcome MeasuresNumber of meiosis II oocytes cryopreserved.A total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy.ResultsA total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy.The combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy.ConclusionThe combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy. ObjectiveTo describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to review the available literature regarding this technique. DesignCase report and literature review. SubjectsA 17-year-old female with a medical history of right ovarian dysgerminoma treated with oophorectomy 3 years prior, who presented with a retroperitoneal mass noted during surveillance. Biopsy of the mass and remaining ovary confirmed recurrent stage III ovarian dysgerminoma. The patient desired fertility preservation. Ovarian tissue cryopreservation and traditional transvaginal oocyte retrieval were contraindicated because of the ovarian malignancy. ExposureThe patient underwent controlled ovarian hyperstimulation with gonadotropins followed by laparotomy and left salpingo-oophorectomy 36 hours after ovulation trigger. An ex vivo retrieval of oocytes was performed under both direct visualization and ultrasound guidance in the operating room after excision of the ovary and isolated using a “mobile IVF” setup. Main Outcome Measure(s)Number of meiosis II oocytes cryopreserved. ResultsA total of 12 meiosis II oocytes were retrieved from the ovary and were successfully cryopreserved. The patient tolerated the procedure well and has since completed chemotherapy. ConclusionThe combination of controlled ovarian hyperstimulation followed by ex vivo oocyte retrieval provides select patients with an opportunity for fertility preservation that may have otherwise faced a complete loss of fertility. In this case, the patient was able to preserve oocytes without jeopardizing her health status or delaying cancer therapy. |
| Author | Mehrhoff, Casey Aston, Kenneth I. Emery, Benjamin R. Childress, Krista J. Cooper, Leah J. Hayes, Katherine G. Letourneau, Joseph M. Luo, Matthew X. Fair, Douglas Alley, Addison W. Kastenberg, Zachary J. Humphreys, Meredith A. |
| Author_xml | – sequence: 1 givenname: Addison W. orcidid: 0000-0002-9478-8083 surname: Alley fullname: Alley, Addison W. email: Addison.alley@hsc.utah.edu organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah – sequence: 2 givenname: Leah J. surname: Cooper fullname: Cooper, Leah J. organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah – sequence: 3 givenname: Meredith A. surname: Humphreys fullname: Humphreys, Meredith A. organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah – sequence: 4 givenname: Benjamin R. surname: Emery fullname: Emery, Benjamin R. organization: Andrology and IVF Laboratory, Department of Urology, University of Utah, Salt Lake City, Utah – sequence: 5 givenname: Kenneth I. surname: Aston fullname: Aston, Kenneth I. organization: Andrology and IVF Laboratory, Department of Urology, University of Utah, Salt Lake City, Utah – sequence: 6 givenname: Zachary J. surname: Kastenberg fullname: Kastenberg, Zachary J. organization: Department of Surgery, University of Utah, Salt Lake City, Utah – sequence: 7 givenname: Matthew X. surname: Luo fullname: Luo, Matthew X. organization: Department of Pathology, University of Utah, Salt Lake City, Utah – sequence: 8 givenname: Katherine G. surname: Hayes fullname: Hayes, Katherine G. organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah – sequence: 9 givenname: Douglas surname: Fair fullname: Fair, Douglas organization: Department of Pediatrics, University of Utah, Salt Lake City, Utah – sequence: 10 givenname: Casey surname: Mehrhoff fullname: Mehrhoff, Casey organization: Department of Pediatrics, University of Utah, Salt Lake City, Utah – sequence: 11 givenname: Joseph M. surname: Letourneau fullname: Letourneau, Joseph M. organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah – sequence: 12 givenname: Krista J. surname: Childress fullname: Childress, Krista J. organization: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah |
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| Cites_doi | 10.1016/j.fertnstert.2021.03.008 10.1007/s10815-011-9596-7 10.1002/cncr.26459 10.1016/j.ygyno.2007.01.036 10.1007/s10815-012-9768-0 10.3322/caac.21763 10.1002/rmb2.12076 10.1016/j.fertnstert.2010.11.023 10.1016/j.fertnstert.2017.05.025 10.3389/fonc.2021.690320 10.1007/s10815-022-02567-0 10.1016/j.fertnstert.2024.01.037 10.1055/s-0040-1718436 10.1016/j.fertnstert.2023.02.010 10.1056/NEJMra1614676 10.1016/j.ygyno.2019.09.012 10.5468/ogs.2015.58.6.537 10.1016/j.fertnstert.2013.07.1992 10.2174/1389201018666170808122531 10.1016/j.fertnstert.2023.01.027 10.1200/JCO.2004.01.159 10.1002/pbc.27297 10.1016/j.bpobgyn.2021.09.010 10.1093/humupd/dml060 10.1159/000481235 10.1093/humrep/det420 |
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| Keywords | case report cancer Fertility preservation oncofertility ex vivo |
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| Snippet | To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma and to... ObjectiveTo describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma... Objective: To describe fertility preservation via ex vivo oocyte retrieval for an adolescent patient undergoing oophorectomy for recurrent ovarian dysgerminoma... |
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| Title | Ex vivo oocyte retrieval for fertility preservation in an adolescent patient with recurrent ovarian dysgerminoma: a case report and review of the literature |
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