Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

• Published in: BMC cancer Vol. 22; no. 1; pp. 1086 - 11
• Main Authors: Tang, Chen-Ling, Tsai, Wei-Chung, Lee, Jui-Ying, Wang, Yao-Kuang, Chen, Yi-Hsun, Liu, Yu-Wei, Lin, Ming-Chieh, Fang, Pen-Tzu, Huang, Yu-Ling, Wu, I-Chen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.10.2022; BioMed Central; BMC
• Subjects: Autonomic nerve system; Autonomic nervous system; Blood pressure; Cancer; Cancer therapies; Care and treatment; Chemoradiotherapy; Chemoradiotherapy - adverse effects; Chemoradiotherapy - methods; Chemotherapy; Electric stimulation; Electrocardiography; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Neoplasms - therapy; Esophageal squamous cell carcinoma; Esophageal Squamous Cell Carcinoma - therapy; Health aspects; Heart beat; Heart Rate; Humans; Mortality; Patient outcomes; Patients; Prognosis; Questionnaires; Radiation therapy; Radiotherapy; Resting heart rate; Skin; Skin sympathetic nerve activity; Software; Squamous cell carcinoma; Survival; Survival analysis; Sympathetic nerves; Sympathetic nervous system; Treatment Outcome; Taiwan; Esophageal squamous cell carcinoma; Resting heart rate; Autonomic nerve system; Chemoradiotherapy; Survival; Skin sympathetic nerve activity

Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer mortality in those with elevated resting heart rates (RHR). Skin sympathetic nerve activit...