Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation

• Published in: Biomaterials Vol. 182; pp. 312 - 322
• Main Authors: Narayanan, Karthikeyan, Kumar, Sundramurthy, Padmanabhan, Parasuraman, Gulyas, Balazs, Wan, Andrew C.A., Rajendran, Vazhaikkurichi M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2018
• Subjects: adipocytes; Adipocytes - metabolism; Adipogenesis; Cell Differentiation; Cell Line; Exosomes; Exosomes - metabolism; Extracellular matrix; Extracellular Matrix - metabolism; gene expression; genes; growth factors; homeostasis; Humans; Lineage determination; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Microenvironment; microRNA; osteoblasts; Osteoblasts - metabolism; Osteogenesis; phenotype; Stem cell fate; stem cells; transcription factors; Lineage determination; Extracellular matrix; Stem cell fate; Microenvironment; Exosomes; Osteogenesis; Adipogenesis

Lineage specification is an essential process in stem cell fate, tissue homeostasis and development. Microenvironmental cues provide direct and selective extrinsic signals to regulate lineage specification of stem cells. Microenvironmental milieu consists of two essential components, one being extra...