The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A

• Published in: Toxicology and applied pharmacology Vol. 273; no. 1; pp. 90 - 99
• Main Authors: Sato, Shoko, Shirakawa, Hitoshi, Tomita, Shuhei, Tohkin, Masahiro, Gonzalez, Frank J., Komai, Michio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.11.2013; Elsevier
• Subjects: 3-METHYLCHOLANTHRENE; 60 APPLIED LIFE SCIENCES; AMINO ACIDS; ANIMAL TISSUES; Animals; Aryl hydrocarbon receptor; Biological and medical sciences; Cercopithecus aethiops; CHROMATIN; Chromatin Immunoprecipitation; COS Cells; DEXAMETHASONE; Dexamethasone - pharmacology; GENES; Glucocorticoid receptor; Hep G2 Cells; Humans; Immunoprecipitation; Medical sciences; MESSENGER-RNA; METALLOTHIONEIN; Metallothionein - genetics; Metallothionein - metabolism; Methylcholanthrene - pharmacology; Promoter Regions, Genetic; Protein Interaction Domains and Motifs - drug effects; RECEPTORS; Receptors, Aryl Hydrocarbon - agonists; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Receptors, Glucocorticoid - agonists; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Response Elements - drug effects; RNA, Messenger - genetics; RNA, Messenger - metabolism; RODENTS; Signal Transduction; Toxicology; Transcription; Transcriptional Activation; Dexamethasone; bHLH/PAS; Transcription; 3-Methylcholanthrene; 3-MC; MT; XRE; AHR; GR; ChIP; Aryl hydrocarbon receptor; MT2A; Dex; Glucocorticoid receptor; GRE; Metallothionein; Human; Corticosteroid; Hydrocarbon; Steroid hormone; Antiinflammatory agent; Ah receptor; 3―Methylcholanthrene; Hormonal receptor; metallothionein 2A; glucocorticoid response element; chromatin immunoprecipitation; xenobiotic response element; basic helix–loop–helix/Per–Arnt–Sim

Although the aryl hydrocarbon receptor (AHR) and glucocorticoid receptor (GR) play essential roles in mammalian development, stress responses, and other physiological events, crosstalk between these receptors has been the subject of much debate. Metallothioneins are classic glucocorticoid-inducible...