Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3

• Published in: Molecular psychiatry Vol. 11; no. 2; pp. 134 - 142
• Main Authors: McQuillin, A, Bass, N J, Kalsi, G, Lawrence, J, Puri, V, Choudhury, K, Detera-Wadleigh, S D, Curtis, D, Gurling, H M D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2006; Nature Publishing Group
• Subjects: Affective disorders; Amino Acid Substitution; Aspartic acid; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Calcium homeostasis; Case-Control Studies; Chromosome 21; Chromosome Mapping; Chromosomes, Human, Pair 21 - genetics; Epilepsy; Gene mapping; Genetic markers; Genetic Predisposition to Disease - genetics; Glutamic acid; Haplotypes; Histidine; Homeostasis; Humans; Linkage Disequilibrium; Medicine; Medicine & Public Health; Microsatellite Repeats - genetics; Microsatellites; Mood Disorders - genetics; Neurosciences; Nucleotide sequence; original-article; Oxidative stress; Pedigree; Peptides; Pharmacotherapy; Polymorphism, Genetic; Psychiatry; Single-nucleotide polymorphism; Susceptibility; Telomeres; Transient receptor potential proteins; TRPM Cation Channels - genetics; manic depression; genetic susceptibility; chromosome 21; linkage disequilibrium

Linkage analyses of bipolar families have confirmed that there is a susceptibility locus near the telomere on chromosome 21q. To fine map this locus we carried out tests of allelic association using 30 genetic markers near the telomere at 21q22.3 in 600 bipolar research subjects and 450 ancestrally...