Skeletal myotube-derived extracellular vesicles enhance itaconate production and attenuate inflammatory responses of macrophages

• Published in: Frontiers in immunology Vol. 14; p. 1099799
• Main Authors: Yamaguchi, Atomu, Maeshige, Noriaki, Yan, Jiawei, Ma, Xiaoqi, Uemura, Mikiko, Matsuda, Mami, Nishimura, Yuya, Hasunuma, Tomohisa, Kondo, Hiroyo, Fujino, Hidemi, Yuan, Zhi-Min
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.03.2023
• Subjects: Animals; extracellular vesicle; Extracellular Vesicles - metabolism; Immunology; IRG1; itaconate; Lipopolysaccharides - pharmacology; macrophage; Macrophages; Mice; MicroRNAs - metabolism; Muscle Fibers, Skeletal - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; skeletal muscle; IRG1; macrophage; itaconate; skeletal muscle; extracellular vesicle

Macrophages play an important role in the innate immunity. While macrophage inflammation is necessary for biological defense, it must be appropriately controlled. Extracellular vesicles (EVs) are small vesicles released from all types of cells and play a central role in intercellular communication....