Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

• Published in: Cellular & molecular biology letters Vol. 23; no. 1; pp. 20 - 19
• Main Authors: Gwangwa, Mokgadi Violet, Joubert, Anna Margaretha, Visagie, Michelle Helen
• Format: Journal Article
• Language: English
• Published: England BioMed Central 04.05.2018; BMC
• Subjects: Animals; Autophagy; Cancer; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Line, Tumor; Glucose - metabolism; Glycolysis; Humans; Metabolic Networks and Pathways; Mice; Mitochondria - metabolism; Oxidation-Reduction; Oxidative Stress; Rats; Review; Warburg effect; Oxidative stress; Autophagy; Cancer; Warburg effect

Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantitie...