Profiling of the full-length transcriptome in abdominal aortic aneurysm using nanopore-based direct RNA sequencing

• Published in: Open biology Vol. 12; no. 2; p. 210172
• Main Authors: Xin, Hai, He, Xingqiang, Li, Jun, Guan, Xiaomei, Liu, Xukui, Wang, Yuewei, Niu, Liyuan, Qiu, Deqiang, Wu, Xuejun, Wang, Haofu
• Format: Journal Article
• Language: English
• Published: England The Royal Society 01.02.2022
• Subjects: abdominal aortic aneurysm; alternative polyadenylation; Alternative Splicing; Aortic Aneurysm, Abdominal - diagnosis; Aortic Aneurysm, Abdominal - genetics; Biomarkers; Computational Biology - methods; Gene Expression Profiling - methods; Gene Expression Regulation; High-Throughput Nucleotide Sequencing - methods; Humans; lncRNAs; Microsatellite Repeats; nanopore-based RNA sequencing; Transcriptome; lncRNAs; nanopore-based RNA sequencing; alternative splicing; abdominal aortic aneurysm; alternative polyadenylation

Abdominal aortic aneurysm (AAA) is a common and serious disease with a high mortality rate, but its genetic determinants have not been fully identified. In this feasibility study, we aimed to elucidate the transcriptome profile of AAA and further reveal its molecular mechanisms through the Oxford Na...