Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

• Published in: Open biology Vol. 11; no. 6; p. 210013
• Main Authors: Balendra, Vyshnavy, Singh, Sandeep Kumar
• Format: Journal Article
• Language: English
• Published: England The Royal Society 30.06.2021
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Antioxidants - metabolism; Antioxidants - pharmacology; Antioxidants - therapeutic use; astaxanthin; Biomarkers; Clinical Studies as Topic; Dietary Supplements; Disease Management; Disease Susceptibility; Drug Evaluation, Preclinical; Humans; neurodegeneration; Neurons - drug effects; Neurons - metabolism; nutraceuticals; oxidative stress; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; Review; superoxide dismutase (SOD); Superoxide Dismutase - metabolism; Superoxide Dismutase - pharmacology; Superoxide Dismutase - therapeutic use; Treatment Outcome; Xanthophylls - metabolism; Xanthophylls - pharmacology; Xanthophylls - therapeutic use; neurodegeneration; superoxide dismutase (SOD); Alzheimer's disease; nutraceuticals; oxidative stress; astaxanthin

Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of exogenous and endogenous antioxidants to maintain homeostasis. Superoxide dismutase (SOD) is an endogenous enzymatic an...