Interplay of reverse transcriptase inhibitor therapy and gag p6 diversity in HIV type 1 subtype G and CRF02_AG

• Published in: AIDS research and human retroviruses Vol. 24; no. 9; p. 1167
• Main Authors: Ojesina, Akinyemi I, Chaplin, Beth, Sankalé, Jean-Louis, Murphy, Robert, Idigbe, Emmanuel, Adewole, Isaac, Ekong, Ernest, Idoko, John, Kanki, Phyllis J
• Format: Journal Article
• Language: English
• Published: United States 01.09.2008
• Subjects: Amino Acid Sequence; Amino Acid Substitution - genetics; gag Gene Products, Human Immunodeficiency Virus - genetics; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; Humans; Molecular Sequence Data; Mutation, Missense; Nigeria; Polymorphism, Genetic; Reverse Transcriptase Inhibitors - pharmacology; Reverse Transcriptase Inhibitors - therapeutic use; Sequence Alignment; Sequence Analysis, DNA; Nigeria

Abstract The gag p6 region of HIV-1 has various nonsubstitutionary mutations, including insertions, duplications, deletions, and premature stop codons. Studies have linked gag p6 mutations to reduced susceptibility to antiretroviral therapy in HIV-1 subtype B. This study examined the relationship be...