Association Between Triglyceride Glucose Index-Waist Circumference and Risk of First Myocardial Infarction in Chinese Hypertensive Patients with Obstructive Sleep Apnoea: An Observational Cohort Study

• Published in: Nature and science of sleep Vol. 14; pp. 969 - 980
• Main Authors: Hu, Junli, Cai, Xintian, Li, Nanfang, Zhu, Qing, Wen, Wen, Hong, Jing, Zhang, Delian, Yao, Xiaoguang, Luo, Qin, Sun, Le
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 31.05.2022; Dove; Dove Medical Press
• Subjects: cohort study; Dextrose; Glucose; Heart attack; Hypertension; myocardial infarction; obstructive sleep apnoea; Original Research; Sleep apnea syndromes; triglyceride glucose index-waist circumference; Triglycerides; China; triglyceride glucose index-waist circumference; cohort study; hypertension; obstructive sleep apnoea; myocardial infarction
• ISSN: 1179-1608; 1179-1608
• DOI: 10.2147/NSS.S362101

This study aimed to investigate the association between triglyceride glucose index-waist circumference (TyG-WC) and the risk of first myocardial infarction (MI) in Chinese hypertensive patients with obstructive sleep apnoea (OSA). This study was an observational cohort study. A total of 2224 Chinese hypertensive patients with OSA without a history of MI were included in this study. Hazard ratio (HR) and 95% confidence interval (CI) were estimated using multivariable Cox proportion hazard models. A generalized additive model was used to identify nonlinear relationships. Additionally, we performed hierarchical analysis and test for interaction. During a median follow-up of 7.15 years, 85 incidents of MI developed. Overall, there was a positive association between TyG-WC and the risk of first MI. In the multivariable-adjusted model, the risk of MI increased with quartiles of the TyG-WC, the HR in quartile 4 versus quartile 1 was 4.29. A generalized additive model and a smooth curve fitting showed that there existed a similar J-shaped association between TyG-WC and the risk of first MI, with an inflection point at about 785. Elevated levels of the baseline TyG-WC are associated with an increased risk of first MI. This finding indicates that the TyG-WC might be useful to identify the high risk of first MI in Chinese hypertensive patients with OSA.