Mitochondrion: a sensitive target for Pb exposure

Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, cardiovascular and nervous systems, etc. Children and...

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Published in	Journal of toxicological sciences Vol. 46; no. 8; pp. 345 - 358
Main Authors	Han, Qing, Zhu, Gaochun, Chen, Hui, Zhang, Wei, Guo, JingChong, Zhu, Qian, Xia, YongLi
Format	Journal Article
Language	English
Published	Japan The Japanese Society of Toxicology 2021 Japan Science and Technology Agency
Subjects	Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Calcium (intracellular) Calcium (mitochondrial) Calcium - metabolism Calcium homeostasis Child Child, Preschool Children Damage Environmental Exposure - adverse effects Environmental Pollutants - adverse effects Environmental Pollutants - toxicity Eukaryotes Exposure Female Food contamination Germination Homeostasis Homeostasis - drug effects Humans Inflammation Inflammation - chemically induced Intelligence Lead Lead - adverse effects Lead - toxicity Male Membrane permeability Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial Permeability Transition Pore Organelles Oxidative stress Oxidative Stress - drug effects Pb exposure Phagocytosis Pregnancy Toxicity Oxidative stress Inflammation Pb exposure Mitochondrial permeability transition pore Autophagy Calcium homeostasis
Online Access	Get full text
ISSN	0388-1350 1880-3989 1880-3989
DOI	10.2131/jts.46.345

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Abstract	Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, cardiovascular and nervous systems, etc. Children and pregnant women are particularly vulnerable to Pb. Pb exposure significantly destroys children’s learning ability, intelligence and perception ability. Mitochondria are involved in various life processes of eukaryotes and are one of the most sensitive organelles to various injuries. There is no doubt that Pb-induced mitochondrial damage can widely affect various physiological processes and cause great harm. In this review, we summarized the toxic effects of Pb on mitochondria which led to various pathological processes. Pb induces mitochondrial dysfunction leading to the increased level of oxidative stress. In addition, Pb leads to cell apoptosis via mitochondrial permeability transition pore (MPTP) opening. Also, Pb can stimulate the development of mitochondria-mediated inflammatory responses. Furthermore, Pb triggers the germination of autophagy via the mitochondrial pathway and induces mitochondrial dysfunction, disturbing intracellular calcium homeostasis. In a word, we discussed the effects of Pb exposure on mitochondria, hoping to provide some references for further research and better therapeutic options for Pb exposure.
AbstractList	Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, cardiovascular and nervous systems, etc. Children and pregnant women are particularly vulnerable to Pb. Pb exposure significantly destroys children’s learning ability, intelligence and perception ability. Mitochondria are involved in various life processes of eukaryotes and are one of the most sensitive organelles to various injuries. There is no doubt that Pb-induced mitochondrial damage can widely affect various physiological processes and cause great harm. In this review, we summarized the toxic effects of Pb on mitochondria which led to various pathological processes. Pb induces mitochondrial dysfunction leading to the increased level of oxidative stress. In addition, Pb leads to cell apoptosis via mitochondrial permeability transition pore (MPTP) opening. Also, Pb can stimulate the development of mitochondria-mediated inflammatory responses. Furthermore, Pb triggers the germination of autophagy via the mitochondrial pathway and induces mitochondrial dysfunction, disturbing intracellular calcium homeostasis. In a word, we discussed the effects of Pb exposure on mitochondria, hoping to provide some references for further research and better therapeutic options for Pb exposure. Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, cardiovascular and nervous systems, etc. Children and pregnant women are particularly vulnerable to Pb. Pb exposure significantly destroys children's learning ability, intelligence and perception ability. Mitochondria are involved in various life processes of eukaryotes and are one of the most sensitive organelles to various injuries. There is no doubt that Pb-induced mitochondrial damage can widely affect various physiological processes and cause great harm. In this review, we summarized the toxic effects of Pb on mitochondria which led to various pathological processes. Pb induces mitochondrial dysfunction leading to the increased level of oxidative stress. In addition, Pb leads to cell apoptosis via mitochondrial permeability transition pore (MPTP) opening. Also, Pb can stimulate the development of mitochondria-mediated inflammatory responses. Furthermore, Pb triggers the germination of autophagy via the mitochondrial pathway and induces mitochondrial dysfunction, disturbing intracellular calcium homeostasis. In a word, we discussed the effects of Pb exposure on mitochondria, hoping to provide some references for further research and better therapeutic options for Pb exposure.Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, cardiovascular and nervous systems, etc. Children and pregnant women are particularly vulnerable to Pb. Pb exposure significantly destroys children's learning ability, intelligence and perception ability. Mitochondria are involved in various life processes of eukaryotes and are one of the most sensitive organelles to various injuries. There is no doubt that Pb-induced mitochondrial damage can widely affect various physiological processes and cause great harm. In this review, we summarized the toxic effects of Pb on mitochondria which led to various pathological processes. Pb induces mitochondrial dysfunction leading to the increased level of oxidative stress. In addition, Pb leads to cell apoptosis via mitochondrial permeability transition pore (MPTP) opening. Also, Pb can stimulate the development of mitochondria-mediated inflammatory responses. Furthermore, Pb triggers the germination of autophagy via the mitochondrial pathway and induces mitochondrial dysfunction, disturbing intracellular calcium homeostasis. In a word, we discussed the effects of Pb exposure on mitochondria, hoping to provide some references for further research and better therapeutic options for Pb exposure.
Author	Zhu, Qian Chen, Hui Xia, YongLi Zhang, Wei Han, Qing Zhu, Gaochun Guo, JingChong
Author_xml	– sequence: 1 fullname: Han, Qing organization: The First Clinical Medical College of Nanchang University, China – sequence: 1 fullname: Zhu, Gaochun organization: Department of Anatomy, Medical College of Nanchang University, China – sequence: 1 fullname: Chen, Hui organization: Department of Anatomy, Medical College of Nanchang University, China – sequence: 1 fullname: Zhang, Wei organization: Department of Anatomy, Medical College of Nanchang University, China – sequence: 1 fullname: Guo, JingChong organization: The First Clinical Medical College of Nanchang University, China – sequence: 1 fullname: Zhu, Qian organization: Department of Anatomy, Medical College of Nanchang University, China – sequence: 1 fullname: Xia, YongLi organization: Department of Anatomy, Medical College of Nanchang University, China
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Snippet	Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds...
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SubjectTerms	Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Calcium (intracellular) Calcium (mitochondrial) Calcium - metabolism Calcium homeostasis Child Child, Preschool Children Damage Environmental Exposure - adverse effects Environmental Pollutants - adverse effects Environmental Pollutants - toxicity Eukaryotes Exposure Female Food contamination Germination Homeostasis Homeostasis - drug effects Humans Inflammation Inflammation - chemically induced Intelligence Lead Lead - adverse effects Lead - toxicity Male Membrane permeability Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial Permeability Transition Pore Organelles Oxidative stress Oxidative Stress - drug effects Pb exposure Phagocytosis Pregnancy Toxicity
Title	Mitochondrion: a sensitive target for Pb exposure
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