Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

• Published in: eLife Vol. 8
• Main Authors: Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Awadalla, P, Battle, A, Bonder, MJ, Boomsma, D, Christiansen, M, Claringbould, A, Deelen, P, van Dongen, J, Esko, T, Favé, M, Franke, L, Frayling, T, Gharib, SA, Gibson, G, Hemani, G, Jansen, R, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Kovacs, P, Krohn, K, Kronberg-Guzman, J, Kukushkina, V, Kutalik, Z, Kähönen, M, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, U, Metspalu, A, van Meurs, J, Milani, L, Müller-Nurasyid, M, Nauck, M, Nivard, M, Penninx, B, Perola, M, Pervjakova, N, Pierce, B, Powell, J, Prokisch, H, Psaty, BM, Raitakari, O, Ring, S, Ripatti, S, Rotzschke, O, Ruëger, S, Saha, A, Scholz, M, Schramm, K, Seppälä, I, Stumvoll, M, Sullivan, P, Teumer, A, Thiery, J, Tong, L, Tönjes, A, Verlouw, J, Visscher, PM, Võsa, U, Völker, U, Yaghootkar, H, Yang, J, Zeng, B, Zhang, F, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 15.01.2019; eLife Sciences Publications, Ltd
• Subjects: Age Factors; Aged; Bayes Theorem; Cardiovascular diseases; complex trait; Dementia disorders; Disease - genetics; DNA Methylation - genetics; Female; FOXO3 protein; Furin; Genetic diversity; Genetic Loci; Genetics and Genomics; Genome-Wide Association Study; Genomics; Homeostasis; Humans; Insulin-like growth factor II receptors; Life span; lifespan; longevity; Longevity - genetics; Lung cancer; Lung diseases; Male; Middle Aged; Multifactorial Inheritance - genetics; Parents; Polymorphism, Single Nucleotide - genetics; Prefrontal cortex; Research Communication; Risk Factors; Sex Characteristics; Signal Transduction - genetics; Survival Analysis; genomics; longevity; genetics; human; complex trait; lifespan

We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify and replicate novel findings near ABO, ZC3HC1, and...