Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population

• Published in: Journal of Zhejiang University. B. Science Vol. 15; no. 3; pp. 264 - 271
• Main Authors: Liang, Shuang, Wang, Xue-lai, Zou, Ming-yang, Wang, Han, Zhou, Xue, Sun, Cai-hong, Xia, Wei, Wu, Li-jie, Fujisawa, Takashi X., Tomoda, Akemi
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.03.2014; Springer Nature B.V
• Subjects: Adolescent; Adult; Asian Continental Ancestry Group - genetics; Autistic Disorder - genetics; Biomedical and Life Sciences; Biomedicine; Child; Child, Preschool; China; DNA - chemistry; DNA - genetics; Endopeptidases - genetics; Family; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; GTPase-Activating Proteins - genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Repressor Proteins - genetics; China; Northeastern Chinese Han population; Autism; Single-nucleotide polymorphism; R179

Objective： A study in a Caucasian population has identified two single-nucleotide polymorphisms （SNPs） in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism. They are located in AUTS1 and AUTS5, which have been identified as autism susceptibility loci in sev...