IL-17 in the immunopathogenesis of spondyloarthritis

• Published in: Nature reviews. Rheumatology Vol. 14; no. 8; pp. 453 - 466
• Main Authors: Taams, Leonie S, Steel, Kathryn J A, Srenathan, Ushani, Burns, Lachrissa A, Kirkham, Bruce W
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.08.2018
• Subjects: Angiogenesis; Animal models; Animals; Ankylosing spondylitis; Antirheumatic Agents - pharmacology; Antirheumatic Agents - therapeutic use; Arthritis; Autoantibodies; Axial skeleton; CD8-Positive T-Lymphocytes - immunology; Cytokines; Gene Expression Regulation - drug effects; Genetic factors; Genetic Testing; Homology; Humans; Immunopathogenesis; Inflammatory diseases; Interleukin 17; Interleukin 23; Interleukin-17 - genetics; Interleukin-17 - metabolism; Interleukin-23 - metabolism; Lymphocytes T; Osteoclastogenesis; Pathogenesis; Psoriatic arthritis; Rheumatic diseases; Signal Transduction - drug effects; Skin; Spondylarthritis - drug therapy; Spondylarthritis - genetics; Spondylarthritis - immunology; Spondylitis; Synovial fluid

Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including...