BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects

• Published in: Molecular psychiatry Vol. 17; no. 6; pp. 597 - 603
• Main Authors: Gerritsen, L, Tendolkar, I, Franke, B, Vasquez, A A, Kooijman, S, Buitelaar, J, Fernández, G, Rijpkema, M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2012; Nature Publishing Group
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Adverse childhood experiences; Alleles; Amygdala; Atrophy; Atrophy - genetics; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain Mapping - methods; Brain Mapping - psychology; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Childhood; Children; Cognition & reasoning; Cortex (cingulate); Cortex (prefrontal); Data processing; Depression; Depression, Mental; Emotions; Female; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genetics; Genotype; Genotype & phenotype; Gyrus Cinguli - pathology; Health aspects; Hippocampus; Homozygotes; Humans; Inventories; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - psychology; Male; Medical imaging; Medical sciences; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Methionine; Middle Aged; Miscellaneous; Mood; Mood disorders; Morphometry; Nerve Fibers, Unmyelinated - pathology; Neuroimaging; Neurosciences; original-article; Pharmacotherapy; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Prefrontal cortex; Psychiatry; Psychological aspects; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Questionnaires; Risk factors; Scanners; Secretion; Self Report; Stress; Stress (Psychology); Stress, Psychological - genetics; Stress, Psychological - pathology; Substantia grisea; Netherlands; voxel-based morphometry; brain-derived neurotrophic factor; imaging genetics; childhood adversities; mood disorders; anterior cingulate cortex; Human; Mood disorder; Volumetric analysis; Healthy subject; anterior cinqulate cortex; Central nervous system; Genotype; Infantile experience; Genetic determinism; Nuclear magnetic resonance imaging; Encephalon; Cingulate cortex; Young adult; Risk factor; Early traumatism; Genetics; Adult; Brain derived neurotrophic factor; Polymorphism; Brain-derived neurotrophic factor; Childhood adversities; Imaging Genetics; Voxel-based morphometry; Anterior Cingulate Cortex

According to the neurotrophic hypothesis of depression, stress can lead to brain atrophy by modifying brain-derived neurotrophic factor (BDNF) levels. Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether...