Serotonin transporter availability in adults with autism—a positron emission tomography study

• Published in: Molecular psychiatry Vol. 26; no. 5; pp. 1647 - 1658
• Main Authors: Andersson, Max, Tangen, Ämma, Farde, Lars, Bölte, Sven, Halldin, Christer, Borg, Jacqueline, Lundberg, Johan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2021; Nature Publishing Group
• Subjects: 59/78; 631/378; 692/699/476/1373; Adult; Autism; Autism Spectrum Disorder - diagnostic imaging; Autistic Disorder - diagnostic imaging; Behavioral Sciences; Biological Psychology; Brain - diagnostic imaging; Brain - metabolism; Brain stem; Carrier proteins; Cognitive ability; Health aspects; Humans; Hypotheses; Medicine; Medicine & Public Health; Neurodevelopment; Neurosciences; Pharmacotherapy; Phenotypes; Physiological aspects; Positron emission tomography; Psychiatry; Serotonin; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Substantia grisea; Tomography; Sweden

Impairments in social interaction and communication, in combination with restricted, repetitive behaviors and interests, define the neurodevelopmental diagnosis of autism spectrum disorder (ASD). The biological underpinnings of ASD are not well known, but the hypothesis of serotonin (5-HT) involveme...