Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

• Published in: Viruses Vol. 14; no. 4; p. 816
• Main Authors: Izumida, Mai, Kotani, Osamu, Hayashi, Hideki, Smith, Chris, Fukuda, Tsutomu, Suga, Koushirou, Iwao, Masatomo, Ishibashi, Fumito, Sato, Hironori, Kubo, Yoshinao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.04.2022; MDPI
• Subjects: Acidification; Acquired immune deficiency syndrome; AIDS; Alkaloids; Alkaloids - pharmacology; antiviral action; Antiviral activity; Antiviral agents; Antiviral Agents - chemistry; Antiviral drugs; antiviral mechanism; Cell adhesion; Chondroitin sulfate; COVID-19 Drug Treatment; Dextran; Dextran Sulfate; Drugs; Ebola virus; Ebolavirus; Ebolavirus - metabolism; emerging viruses; Endocytosis; Endosomes; Epidemics; Gag protein; Genomes; Glycoproteins; Hemorrhagic Fever, Ebola - drug therapy; Heparin; Heparin - pharmacology; HIV; Human immunodeficiency virus; Humans; Infections; Laboratories; lamellarin α 20-sulfate; marine alkaloid; Npc1 protein; Plasmids; pseudotyped lentiviral vector; Reagents; RNA viruses; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Virus Internalization; Viruses; pseudotyped lentiviral vector; emerging viruses; marine alkaloid; molecular dynamics simulation; antiviral mechanism; lamellarin α 20-sulfate; antiviral action; docking simulation

Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1. We explored the antiviral action and mechanisms of this alkaloid against emerging enveloped RNA viruses that use endocytosi...