Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2 - Izumida, Mai; Kotani, Osamu; Hayashi, Hideki; Smith, Chris; Fukuda, Tsutomu; Suga, Koushirou; Iwao, Masatomo; Ishibashi, Fumito; Sato, Hironori; Kubo, Yoshinao (Viruses, 2022)
Keywords: Acidification; Acquired immune deficiency syndrome; AIDS; Alkaloids; Alkaloids - pharmacology; antiviral action; Antiviral activity; Antiviral agents; Antiviral Agents - chemistry; Antiviral drugs; antiviral mechanism; Cell adhesion; Chondroitin sulfate; COVID-19 Drug Treatment; Dextran; Dextran Sulfate; Drugs; Ebola virus; Ebolavirus; Ebolavirus - metabolism; emerging viruses; Endocytosis; Endosomes; Epidemics; Gag protein; Genomes; Glycoproteins; Hemorrhagic Fever, Ebola - drug therapy; Heparin; Heparin - pharmacology; HIV; Human immunodeficiency virus; Humans; Infections; Laboratories; lamellarin α 20-sulfate; marine alkaloid; Npc1 protein; Plasmids; pseudotyped lentiviral vector; Reagents; RNA viruses; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Virus Internalization; Viruses; pseudotyped lentiviral vector; emerging viruses; marine alkaloid; molecular dynamics simulation; antiviral mechanism; lamellarin α 20-sulfate; antiviral action; docking simulation