Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 5; pp. 1332 - 1339.e3
• Main Authors: Van Gerven, Laura, Alpizar, Yeranddy A., Wouters, Mira M., Hox, Valérie, Hauben, Esther, Jorissen, Mark, Boeckxstaens, Guy, Talavera, Karel, Hellings, Peter W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2014; Elsevier; Elsevier Limited
• Subjects: Adult; afferent nerves; Allergies; Allergy and Immunology; Biological and medical sciences; Capsaicin - administration & dosage; Capsaicin - adverse effects; Capsaicin treatment; Cells, Cultured; Cocaine; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation - drug effects; Humans; idiopathic rhinitis; Immunopathology; Male; Mast Cells - metabolism; Mast Cells - pathology; Medical sciences; Middle Aged; nasal hyperreactivity; Nasal Mucosa - metabolism; Nasal Mucosa - pathology; Nasal Sprays; Neuropeptides; Non tumoral diseases; Nose; Otolaryngology; Otorhinolaryngology. Stomatology; Proto-Oncogene Proteins c-kit - biosynthesis; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Perennial - metabolism; Rhinitis, Allergic, Perennial - pathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sensory System Agents - administration & dosage; Sensory System Agents - adverse effects; TRPV Cation Channels - biosynthesis; TRPV1; TRPV1-SP signaling pathway; Ubiquitin Thiolesterase - biosynthesis; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; CDA; afferent nerves; TRE; idiopathic rhinitis; PGP 9.5; VAS; NANIR; Capsaicin treatment; FITC; TUNEL; SPT; NHR; TRPM8; SP; nasal hyperreactivity; TRPA1; NKA; TRPV1-SP signaling pathway; IR; TRPV1; NEC; PI; HC; CGRP; PNIF; Fluorescein isothiocyanate; Calcitonin gene–related peptide; Transient receptor potential cation channel subfamily M, receptor 8; Propidium iodide; Terminal deoxynucleotide transferase dUTP nick end labeling; Cold dry air; Visual analog scale; Therapeutic response evaluation; Transient receptor potential cation channel subfamily V, receptor 1; Neurokinin A; Protein gene product 9.5; Healthy control subject; Substance P; Skin prick test; Nonallergic noninfectious rhinitis; Peak nasal inspiratory flow; Nasal epithelial cell; Transient receptor potential cation channel subfamily A, receptor 1; Human; Immunopathology; Nose disease; Hyperreactivity; Rhinitis; Capsaicin; Idiopathic; Gene overexpression; Ionic channel; Transitory; Nerve; Immunology; Treatment; Signaling pathway; Nose; ENT disease; Cations; TRPVI-SP signaling pathway; Biological receptor

Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. We sought to investigate the molecular and cellular bases of IR and the therapeutic action...