Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

• Published in: Journal of hepatology Vol. 60; no. 4; pp. 824 - 831
• Main Authors: Vrieze, Anne, Out, Carolien, Fuentes, Susana, Jonker, Lisanne, Reuling, Isaie, Kootte, Ruud S., van Nood, Els, Holleman, Frits, Knaapen, Max, Romijn, Johannes A., Soeters, Maarten R., Blaak, Ellen E., Dallinga-Thie, Geesje M., Reijnders, Dorien, Ackermans, Mariëtte T., Serlie, Mireille J., Knop, Filip K., Holst, Jenst J., van der Ley, Claude, Kema, Ido P., Zoetendal, Erwin G., de Vos, Willem M., Hoekstra, Joost B.L., Stroes, Erik S., Groen, Albert K., Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2014
• Subjects: adiposity; Administration, Oral; Adult; Aged; Amoxicillin; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Antibiotics; Bile acids; Bile Acids and Salts - blood; Bile Acids and Salts - metabolism; capacity; diet-induced obesity; energy-expenditure; Feces - chemistry; Feces - microbiology; Gastroenterology and Hepatology; glucagon; Glucose - metabolism; Humans; Insulin Resistance; Intestinal microbiota; Intestines - drug effects; Intestines - microbiology; Male; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - drug therapy; Metabolic Syndrome - microbiology; Mice; Microbiota - drug effects; Middle Aged; Obesity - complications; Obesity - drug therapy; Obesity - microbiology; resistance; salt hydrolase activity; Single-Blind Method; Vancomycin; Vancomycin - administration & dosage; Vancomycin - adverse effects; Bile acids; Antibiotics; Intestinal microbiota; Amoxicillin; Insulin resistance; Vancomycin; Metabolic syndrome

Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fe...