Engineering of Yarrowia lipolytica transporters for high-efficient production of biobased succinic acid from glucose

• Published in: Biotechnology for biofuels Vol. 14; no. 1; p. 145
• Main Authors: Jiang, Zhennan, Cui, Zhiyong, Zhu, Ziwei, Liu, Yinghang, Tang, Ya-jie, Hou, Jin, Qi, Qingsheng
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 27.06.2021; BioMed Central; BMC
• Subjects: Analysis; Batch culture; batch fermentation; Biodegradable materials; biofuels; Biosynthesis; Biotechnology; carbon; Cell growth; Dextrose; Dicarboxylic acids; Efficiency; Engineering; Fermentation; Genetic aspects; Glucose; Glucose fermentation; Identification and classification; Industrial production; industry; Metabolism; Metabolites; Methods; Mitochondria; Physiological aspects; Secretion; Succinic acid; Transporter engineering; Tricarboxylic acid cycle; Yarrowia lipolytica; Yeast; Yeast fungi; yeasts; China

Succinic acid (SA) is a crucial metabolic intermediate and platform chemical. Development of biobased processes to achieve sustainable SA production has attracted more and more attention in biotechnology industry. Yarrowia lipolytica has a strong tricarboxylic acid cycle and tolerates low pH conditi...