Fibroblast growth factor 15/19 expression, regulation, and function: An overview

• Published in: Molecular and Cellular Endocrinology Vol. 548; p. 111617
• Main Authors: Guthrie, Greg, Vonderohe, Caitlin, Burrin, Douglas
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.05.2022; Elsevier BV
• Subjects: Bile acid metabolism; bile acids; Bile Acids and Salts; Carbohydrate metabolism; embryogenesis; Endocrine System; Endocrine System - metabolism; endocrinology; energy expenditure; Farnesoid x receptor; Fibroblast growth factor 19; Fibroblast Growth Factors; Fibroblast Growth Factors - metabolism; Glucose; Glucose - metabolism; homeostasis; Humans; Lipid metabolism; peptides; Protein synthesis; Signal Transduction; Farnesoid x receptor; Carbohydrate metabolism; Lipid metabolism; Protein synthesis; Fibroblast growth factor 19; Bile acid metabolism

Since the discovery of fibroblast growth factor (FGF)-19 over 20 years ago, our understanding of the peptide and its role in human biology has moved forward significantly. A member of a superfamily of paracrine growth factors regulating embryonic development, FGF19 is unique in that it is a dietary-...