Retinal gap junctions are involved in rhythmogenesis of neuronal activity at remote locations – Study on infra-slow oscillations in the rat olivary pretectal nucleus

• Published in: Neuroscience Vol. 339; pp. 150 - 161
• Main Authors: Orlowska-Feuer, Patrycja, Jeczmien-Lazur, Jagoda S., Szkudlarek, Hanna J., Lewandowski, Marian H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 17.12.2016
• Subjects: Animals; Carbenoxolone - pharmacology; Dose-Response Relationship, Drug; gap junctions; Gap Junctions - drug effects; Gap Junctions - physiology; in vivo electrophysiology; infra-slow rhythm; intraocular injections; Intravitreal Injections; light responses; Male; Meclofenamic Acid - pharmacology; Neural Pathways - drug effects; Neural Pathways - physiology; Neurology; Periodicity; Peripheral Nervous System Agents - pharmacology; Pretectal Region - physiology; Rats; Rats, Wistar; Retina - drug effects; Retina - physiology; Vision, Ocular - drug effects; Vision, Ocular - physiology; PBS; gap junctions; RGCs; infra-slow rhythm; MFA; intraocular injections; LED; OPN; light responses; 2-APB; GJs; ipRGCs; in vivo electrophysiology; PSTHs; ChSB; Cx; FFT; CBX; IB; EB; light emitting diode; Chicago Sky Blue; carbenoxolone; intrinsically photosensitive retinal ganglion cells; retinal ganglion cells; buffered physiological saline; Fast Fourier Transform; 2-aminoethoxydiphenylborane; connexins; extraburst; olivary pretectal nucleus; intraburst; meclofenamic acid; peri-stimulus time histograms

•Pharmacological blockade of retinal gap junctions with CBX or MFA leads to abolition of infra-slow oscillations in the OPN.•The effect of CBX on light-induced responses of the OPN oscillatory cells is GJs independent.•Retinal synchrony might be crucial for the expression of the infra-slow rhythm at...