Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells

• Published in: Life (Basel, Switzerland) Vol. 12; no. 11; p. 1855
• Main Authors: Rednic, Robert, Macasoi, Ioana, Pinzaru, Iulia, Dehelean, Cristina Adriana, Tomescu, Mirela-Cleopatra, Susan, Monica, Feier, Horea
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2022; MDPI
• Subjects: Acids; Actin; Anticancer properties; Antitumor activity; Apoptosis; Betulinic acid; Blood vessels; Cancer therapies; Cell death; Cell viability; Chorioallantoic membrane; Chromatin; Cytotoxicity; Digitalis; Digoxin; Drug synergism; Drug therapy; Eggs; Evaluation; F-actin fibers; Fibers; HET-CAM assay; Melanoma; melanoma cells; Morphology; Pharmacology, Experimental; Phytochemicals; Plant species; Reagents; Skin cancer; synergic effect; Testing; Triterpenes; Tumor cells; Romania; United States > US; Germany; digoxin; F-actin fibers; betulinic acid; synergic effect; melanoma cells; HET-CAM assay

Betulinic acid, a small molecule from pentacyclic triterpenes class, has been widely studied for its antitumor activity, revealing that it induces the apoptosis of tumor cells in a selective manner. In recent years, digoxin, a cardiac glycoside found particularly in the plant species , has drawn int...